ArticleJournal of autism and developmental disorders2016
Sex Differences in Internalizing Problems During Adolescence in Autism Spectrum Disorder.
Article in Journal of autism and developmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Exercise dose architecture as a precision-informed developmental framework in autism spectrum disorder: a narrative review of mechanisms, sex- and development-related heterogeneity, and clinical translation.Frontiers in psychiatry · 2026Pooled it
- Is There a Bias Towards Males in the Diagnosis of Autism? A Systematic Review and Meta-Analysis.Neuropsychology review · 2025Pooled it
- Experiences of females on the autism spectrum through the perspective of minority stress theory: a review.Frontiers in psychiatry · 2025Pooled it
- IQ and Internalising Symptoms in Adolescents with ASD.Journal of autism and developmental disorders · 2021Pooled it
- Anxiety and intellectual functioning in autistic children: A systematic review and meta-analysis.Autism : the international journal of research and practice · 2021Pooled it
- An Initial Case Series of Intensive Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in Adolescents with Autism Spectrum Disorder.Child psychiatry and human development · 2018Trial
- Examining the association between autistic traits and psychopathology in the general population: are there sex differences?European archives of psychiatry and clinical neuroscience · 2026Article
- Clinical Characteristics and Blood-Based Inflammatory Indices of Psychiatric Hospitalizations Among Children with Autism in China: A Retrospective Electronic Medical Records Study.Brain sciences · 2026Article
- Sex Differences in Psychopathology and Neurocognition in Community Youth With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Exploring Trajectories of Anxiety Symptoms in Autistic and Non-Autistic Youth over Adolescence Using Parent- and Self-Report Measures.Research in autism · 2026Article
- A multi-method phenotypic study of sex differences in pragmatic language in autism.Frontiers in psychiatry · 2026Article
- Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth.Frontiers in psychiatry · 2026Article
- Autism in Adulthood: Psychiatric Comorbidity in High-Functioning Autistic Adults in an Outpatient Clinical Population.NeuroSci · 2025Article
- Characterizing Mental Health Symptoms and Caregiver Priorities for Autistic Children Receiving Publicly-Funded Mental Health Services: A Latent Class Analysis.Evidence-based practice in child and adolescent mental health · 2025Article
- Longitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials.Psychological medicine · 2025Article
- EEG Abnormalities and Phenotypic Correlates in Preschoolers with Autism Spectrum Disorder: A Single-Center Study.Journal of clinical medicine · 2025Article
- Sex differences in the prevalence of common comorbidities in autism: a narrative review.Ewha medical journal · 2025Review
- A good autistic life: an autistic-led conceptualization of autistic flourishing through autistic women's-lived experiences.Frontiers in sociology · 2025Article
- Functional Neurological Disorder and Autism Spectrum Disorder: A Complex and Potentially Significant Relationship.Brain and behavior · 2024Review
- Camouflaging in neurodivergent and neurotypical girls at the transition to adolescence and its relationship to mental health: A participatory methods research study.JCPP advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that the double hit conferred by sex and diagnosis increases the risk for internalizing disorders in adolescent females with autism spectrum disorder (ASD). In a sample of 32 adolescents with ASD and 32 controls, we examined the effects of sex, diagnostic factors, and developmental stages on depression and anxiety. A 3-way interaction revealed that females with ASD exhibited greater depressive symptoms than males with ASD and female controls particularly during early adolescence; therefore, females with ASD might have a unique combination of genetic, hormonal, and psychosocial vulnerabilities that heighten their risk for depression during early adolescence. Additionally, the ASD group reported high levels of separation anxiety and panic in late adolescence, possibly indicating atypical development of independence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.