ArticleDiabetes2016
Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control.
Article in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01394627 (Hypoglycemia and the Mineralocorticoid Receptor), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypoglycemia and the Mineralocorticoid Receptor
Who cites it
13 citing papers in PubMed.
- Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial.The Journal of clinical endocrinology and metabolism · 2025Trial
- ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure.The Journal of clinical endocrinology and metabolism · 2020Trial
- Real-time autonomic responses to insulin-induced hypoglycaemia in volunteers with type I diabetes compared to controls.IBRO neuroscience reports · 2026Article
- Association between hypoglycemia unawareness and cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus: a prospective cohort study.Diabetology & metabolic syndrome · 2025Article
- Effect of hypoglycemia on baroreflex sensitivity in individuals with type 2 diabetes: implications for autonomic control of cardiovascular function in diabetes.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- The Effect of Exercise on Cardiovascular Autonomic Nervous Function in Patients with Diabetes: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Stress, hypoglycemia, and the autonomic nervous system.Autonomic neuroscience : basic & clinical · 2022Review
- Atherosclerosis Risk Factors in Patients with Reactive Hypoglycemia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association of glycemic variability and hypoglycemia with distal symmetrical polyneuropathy in adults with type 1 diabetes.Scientific reports · 2021Article
- Association between Changes in the Systolic Blood Pressure from Evening to the Next Morning and Night Glucose Variability in Heart Disease Patients.Internal medicine (Tokyo, Japan) · 2021Article
- Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies.Journal of diabetes investigation · 2020Review
- Cardiac Autonomic Regulation and Repolarization During Acute Experimental Hypoglycemia in Type 2 Diabetes.Diabetes · 2017Article
- Dysregulation of microRNAs and renin-angiotensin system in high salt diet-induced cardiac dysfunction in uninephrectomized rats.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Studies have shown associations between exposure to hypoglycemia and increased mortality, raising the possibility that hypoglycemia has adverse cardiovascular effects. In this study, we determined the acute effects of hypoglycemia on cardiovascular autonomic control. Seventeen healthy volunteers were exposed to experimental hypoglycemia (2.8 mmol/L) for 120 min. Cardiac vagal baroreflex function was assessed using the modified Oxford method before the initiation of the hypoglycemic-hyperinsulinemic clamp protocol and during the last 30 min of hypoglycemia. During hypoglycemia, compared with baseline euglycemic conditions, 1) baroreflex sensitivity decreases significantly (19.2 ± 7.5 vs. 32.9 ± 16.6 ms/mmHg, P < 0.005), 2) the systolic blood pressure threshold for baroreflex activation increases significantly (the baroreflex function shifts to the right; 120 ± 14 vs. 112 ± 12 mmHg, P < 0.005), and 3) the maximum R-R interval response (1,088 ± 132 vs. 1,496 ± 194 ms, P < 0.001) and maximal range of the R-R interval response (414 ± 128 vs. 817 ± 183 ms, P < 0.001) decrease significantly. These findings indicate reduced vagal control and impaired cardiovascular homeostasis during hypoglycemia.
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Registered trials
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