Evidence map›Paper›PMID 26438595›Full record

ReviewCold Spring Harbor perspectives in biology2016

In Vitro Models for Neurogenesis.

Hassan Azari, Brent A Reynolds

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hassan AzariDepartment of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611 Neural Stem Cell and Regenerative Neuroscience Laboratory, Department of Anatomical Sciences & Shiraz Stem Cell Institute, Shiraz University of Medical Sciences, Shiraz, Iran.
Brent A ReynoldsDepartment of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The process of generating new neurons of different phenotype and function from undifferentiated stem and progenitor cells starts at very early stages of development and continues in discrete regions of the mammalian nervous system throughout life. Understanding mechanisms underlying neuronal cell development, biology, function, and interaction with other cells, especially in the neurogenic niche of fully developed adults, is important in defining and developing new therapeutic regimes in regenerative neuroscience. Studying these complex and dynamic processes in vivo is challenging because of the complexity of the nervous system and the presence of many known and unknown confounding variables. However, the challenges could be overcome with simple and robust in vitro models that more or less recapitulate the in vivo events. In this work, we will present an overview of present available in vitro cell-based models of neurogenesis.

Indexed as

Cell DifferentiationAnimalsBrainCoculture TechniquesGene Expression ProfilingHumansNeural Stem CellsNeurogenesisNeuronsPhenotypePluripotent Stem CellsSignal Transduction

Identifiers

PMID26438595
PMCPMC4888817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.