ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2015
Pediatric gliosarcoma treated with adjuvant radiotherapy and temozolomide.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Pediatric gliosarcoma, a rare central nervous system tumor in children: Case report and literature review.Heliyon · 2023Article
- Gliosarcoma in patients under 20 years of age. A clinicopathologic study of 11 cases and detailed review of the literature.BMC pediatrics · 2021Review
- Retrobulbar chlorpromazine injection in a child with gliosarcoma invasion into the orbits.BMJ case reports · 2020Article
- Pineal gliosarcoma in a 5-year-old girl.Radiology case reports · 2018Article
- Extent of surgical resection and adjuvant temozolomide improves survival in pediatric GBM: a single center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
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7 authors at 1 institution in 1 country.
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Abstract
purposePrimary pediatric gliosarcoma (pPGS) is an extremely rare entity with only 25 cases reported in the English literature. The value of concurrent and adjuvant temozolomide is not known in this group of patient.
methodsFive patients of pPGS treated from 2006 to 2011 were included in this retrospective analysis. All patients underwent maximal safe surgical resection. Adjuvant therapy included conformal radiation 60 Gy in 30 fractions (2 Gy daily for 5 days in a week) with concurrent temozolomide 75 mg/m(2) daily followed by six cycles of maintenance temozolomide 150-200 mg/m(2) (day 1 to day 5) every 4 weeks. We combined the survival data of 25 patients (already published) and five of our patients and analyzed them in terms of progression free survival (PFS) and overall survival (OS) using Kaplan-Meier method.
resultsMale to female ratio was 1:4 and median age was 12 years (range, 7-19 years). All but one patient underwent gross total resection and four patients completed adjuvant radiotherapy as well as concurrent and adjuvant temozolomide. At a median follow up of 22.6 months (range, 0 to 45.3 months), two patients were dead and two were alive without disease while one was lost to follow up. For the pooled data, estimated median PFS and OS of all 30 patients reported in literature were 12 and 43 months, respectively. Two years PFS and OS rate for all patients was 44.2 and 62.9%, respectively.
conclusionAdjuvant radiotherapy and temozolomide is well tolerated and show an encouraging survival in pPGS.
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