Evidence map›Paper›PMID 26438454›Full record

ReviewNeurocritical care2015

Emergency Neurological Life Support: Pharmacotherapy.

Gretchen M Brophy, Theresa Human, Lori Shutter

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurocritical care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Managing Intracranial Pressure Crisis.Current neurology and neuroscience reports · 2024
    Review
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Neurocritical care update.Journal of intensive care · 2016
    Review
  8. Erratum to: Neurocritical care update.Journal of intensive care · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Gretchen M BrophyDepartments of Pharmacotherapy & Outcomes Science and Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA. gbrophy@vcu.edu.
Theresa HumanDepartment of Clinical Pharmacy, Barnes-Jewish Hospital, Washington University in St. Louis, St. Louis, MO, USA.
Lori ShutterDepartments of Critical Care Medicine, Neurology & Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Pittsburgh · USVirginia Commonwealth University · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The appropriate use of medications during Emergency Neurological Life Support (ENLS) is essential to optimize patient care. Important considerations when choosing the appropriate agent include the patient's organ function and medication allergies, potential adverse drug effects, drug interactions, and critical illness and aging pathophysiologic changes. Critical medications used during ENLS include hyperosmolar therapy, anticonvulsants, antithrombotics, anticoagulant reversal and hemostatic agents, anti-shivering agents, neuromuscular blockers, antihypertensive agents, sedatives, vasopressors and inotropes, and antimicrobials. This article focuses on the important pharmacokinetic and pharmacodynamics characteristics, advantages and disadvantages, and clinical pearls of these therapies, providing practitioners with essential drug information to optimize pharmacotherapy in acutely ill neurocritical care patients.

Indexed as

Drug InteractionsDrug-Related Side Effects and Adverse ReactionsPharmacokineticsEmergency TreatmentHumansLife Support CareNervous System DiseasesAdverse drug eventDrug interactionENLSMedicationPharmacotherapy

Identifiers

PMID26438454
OpenAlexW2266302340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.