ArticleBMC gastroenterology2015
Factors associated with growth disturbance at celiac disease diagnosis in children: a retrospective cohort study.
Article in BMC gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Growth patterns in coeliac disease - a longitudinal study of children aged 0-6 years in Sweden.BMC pediatrics · 2026Observational
- Changes in the anthropometric measurements in children and adolescents with coeliac disease over a two-year follow-up.European journal of pediatrics · 2025Observational
- Effect of Gluten-Free Diet on Metabolic Control and Growth Parameters Among Children and Adolescents With Type 1 Diabetes During the First Year After Diagnosis of Celiac Disease: A Retrospective Case-Control Study.Pediatric diabetes · 2025Article
- Compliance and Lifestyle of Children with Celiac Disease in the Iranian Children.Advanced biomedical research · 2024Article
- Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?Nutrients · 2023Article
- An Evaluation of Nutritional Status and Problems with Dietary Compliance in Polish Patients with Celiac Disease.Nutrients · 2022Article
- Impact of diagnostic delay to the clinical presentation and associated factors in pediatric inflammatory bowel disease: a retrospective study.BMC gastroenterology · 2021Article
- Prevalence and Clinical Features of Celiac Disease in a Cohort of Italian Children with Autism Spectrum Disorders.Nutrients · 2021Article
- Celiac disease in children: Increasing prevalence and changing clinical presentations.Clinical and experimental pediatrics · 2021Article
- Progression of pediatric celiac disease from potential celiac disease to celiac disease: a retrospective cohort study.BMC pediatrics · 2021Article
- The impact of symptoms on quality of life before and after diagnosis of coeliac disease: the results from a Polish population survey and comparison with the results from the United Kingdom.BMC gastroenterology · 2021Article
- Intestinal Microbiota in Common Chronic Inflammatory Disorders Affecting Children.Frontiers in immunology · 2021Review
- Frequency of oligosymptomatic gastrointestinal tract diseases and its relation to insulin-like growth factor I in idiopathic (non-GH-deficient) short stature children.Archives of medical science : AMS · 2021Article
- Childhood growth prior to screen-detected celiac disease: prospective follow-up of an at-risk birth cohort.Scandinavian journal of gastroenterology · 2020Article
- Type 1 tyrosinemia in Finland: a nationwide study.Orphanet journal of rare diseases · 2020Article
- Linear growth of children with celiac disease after the first two years on gluten- free diet: a controlled study.Acta bio-medica : Atenei Parmensis · 2019Article
- Article
- Failure to Thrive: An Expanded Differential Diagnosis.Journal of pediatric genetics · 2019Article
- Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?Gastroenterology research and practice · 2019Review
- Extra-Intestinal Manifestations of Coeliac Disease in Children: Clinical Features and Mechanisms.Frontiers in pediatrics · 2019Review
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired growth is a well-known complication in celiac disease, but factors associated with it are poorly known. We investigated this issue in a large cohort of children.
methods530 children with biopsy-proven celiac disease were included. The participants were divided into two groups on the basis of the presence (n = 182) or absence (n = 348) of growth disturbance at diagnosis. Histological, serological and clinical characteristics were compared between children with growth failure and those with normal growth. Further, patients with growth failure as the sole clinical presentation were compared to those with poor growth and concomitant other symptoms.
resultsChildren with growth failure were younger (p < 0.001) and had lower hemoglobin (p = 0.016) and higher celiac antibody (p < 0.001), alanine aminotransferase (p = 0.035) and thyroid-stimulating hormone values (p = 0.013) than those with normal growth. Significantly associated with growth failure at diagnosis were age <3 years (OR 4.3 (95 % CI 2.5-7.5) vs older age), diagnosis before the year 2000 and in 2000-09 (OR 3.1 (1.8-5.4) and OR 1.8 (1.1-2.8) vs diagnosis in 2010-2013), presence of total and subtotal villous atrophy (OR 4.2 (2.5-7.0) and OR 2.0 (1.3-3.2) vs partial atrophy), severe symptoms (OR 3.4 (1.8-6.7) vs mild symptoms) and vomiting (OR 3.1 (1.5-6.3). The presence of abdominal pain reduced the risk (OR 0.5 (0.3-0.7)), while there was no effect of gender, diarrhea, constipation, other chronic diseases and celiac disease in the family. Children evincing poor growth as the sole clinical presentation were older (p < 0.001) and had higher hemoglobin (P < 0.001) and total iron (p = 0.010) values and lower TG2ab values (p = 0.009) than those with growth disturbance and other symptoms.
conclusionsIn particular young age and severe clinical and histological presentation were associated with growth disturbance at celiac disease diagnosis. Children with only poor growth are markedly different from those with other concomitant symptoms, suggesting different pathogenic mechanisms.
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