Evidence map›Paper›PMID 26438258›Full record

ArticleBMC research notes2015

The pla gene, encoding plasminogen activator, is not specific to Yersinia pestis.

Stephanie Hänsch, Elisabetta Cilli, Giulio Catalano, Giorgio Gruppioni, Raffaella Bianucci, Nils C Stenseth, Barbara Bramanti, Mark J Pallen

Abstract readLetter
In one paragraph

Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026
    Review
  2. Article
  3. Article
  4. Multiplex PCR System for the Diagnosis of Plague.Current molecular medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020
    Review
  12. Biomolecules · 2020
    Review
  13. Article
  14. Article
  15. Article
  16. AncientProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephanie HänschCentre for Ecological and Evolutionary Synthesis, University of Oslo, Oslo, Norway. stephanie.hansch@ibv.uio.no.
Elisabetta CilliDepartment of Cultural Heritage, University of Bologna, Ravenna Campus, Bologna, Italy. elisabetta.cilli@unibo.it.
Giulio CatalanoDepartment of Cultural Heritage, University of Bologna, Ravenna Campus, Bologna, Italy. giulio.catalano@unibo.it.
Giorgio GruppioniDepartment of Cultural Heritage, University of Bologna, Ravenna Campus, Bologna, Italy. giorgio.gruppioni@unibo.it.
Raffaella BianucciCentre for Ecological and Evolutionary Synthesis, University of Oslo, Oslo, Norway. raffaella.bianucci@gmail.com.
Nils C StensethCentre for Ecological and Evolutionary Synthesis, University of Oslo, Oslo, Norway. n.c.stenseth@ibv.uio.no.
Barbara BramantiCentre for Ecological and Evolutionary Synthesis, University of Oslo, Oslo, Norway. barbara.bramanti@ibv.uio.no.
Mark J PallenMicrobiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK. m.pallen@warwick.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we present evidence to show that the pla gene, previously thought to be specific to Yersinia pestis, occurs in some strains of Citrobacter koseri and Escherichia coli. This means that detection of this gene on its own can no longer be taken as evidence of detection of Y. pestis.

Indexed as

Conserved SequenceArchaeologyBacterial ProteinsBase SequenceCitrobacter koseriEscherichia coliFossilsGene ExpressionMolecular Sequence DataPlasmidsPlasminogen ActivatorsPolymerase Chain ReactionSequence AlignmentSequence Analysis, DNAYersinia pestisBacterial ProteinsPla protease, Yersinia pestisPlasminogen Activators

Identifiers

PMID26438258
PMCPMC4593223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.