ReviewIntensive care medicine2015
Did studies on HFOV fail to improve ARDS survival because they did not decrease VILI? On the potential validity of a physiological concept enounced several decades ago.
Review in Intensive care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP)Therapeutic advances in respiratory diseasePooled it
- Influence of the mean airway pressure trajectory on the mortality and AKI occurrence in septic shock patients with mechanical ventilation: insights from the MIMIC-IV database.Frontiers in medicine · 2025Article
- Lung-protective ventilation in the management of congenital diaphragmatic hernia.World journal of pediatric surgery · 2024Review
- The Physiological Basis of High-Frequency Oscillatory Ventilation and Current Evidence in Adults and Children: A Narrative Review.Frontiers in physiology · 2022Review
- Oscillatory ventilation redux: alternative perspectives on ventilator-induced lung injury in the acute respiratory distress syndrome.Current opinion in physiology · 2021Review
- High-Frequency Oscillatory Ventilation and Ventilator-Induced Lung Injury: Size Does Matter.Critical care medicine · 2020Article
- Comparison of the ventilation characteristics in two adult oscillators: a lung model study.Intensive care medicine experimental · 2019Article
- Intensive care medicine in 2050: ventilator-induced lung injury.Intensive care medicine · 2018Article
- The future of mechanical ventilation: lessons from the present and the past.Critical care (London, England) · 2017Review
- Some remaining important questions after LUNG SAFE : Discussion of "Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study".Intensive care medicine · 2017Article
- Effect of high-frequency oscillatory ventilation on esophageal and transpulmonary pressures in moderate-to-severe acute respiratory distress syndrome.Annals of intensive care · 2016Article
- Any trial can (almost) kill a good technique.Intensive care medicine · 2016Article
- What the concept of VILI has taught us about ARDS management.Intensive care medicine · 2016Article
- Does high-pressure, high-frequency oscillation shake the foundations of lung protection?Intensive care medicine · 2015Article
- Does the use of high PEEP levels prevent ventilator-induced lung injury?Revista Brasileira de terapia intensivaReview
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High frequency oscillatory ventilation (HFOV) has been the subject of extensive physiological research for 30 years and even more so of an intense debate on its potential usefulness in the treatment of acute respiratory distress syndrome (ARDS). This technique has been enthusiastically promoted by some teams until two high-quality randomized clinical trials in adults with ARDS showed that HFOV did not decrease and might have even increased mortality. As a consequence of these results, physiological concepts such as atelectrauma and biotrauma on which ARDS management with HFOV were based should be reexamined. In contrast, the concept of volutrauma, i.e., end-inspiratory overdistension, as the cause for ventilator-induced lung injury might help explain excess mortality during mechanical ventilation of ARDS when inspiratory volumes are too high. This is what might have happened during one of the recent studies on HFOV. Failure of this complex technique must be put in perspective with the dramatic improvement of ARDS prognosis with very simple interventions such as tidal volume reduction, early pharmacological paralysis, and prone positioning which all limited end-inspiratory volume.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.