ArticleSurgery today2016
Influence of nutritional status on the therapeutic effect of infliximab in patients with Crohn's disease.
Article in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Systematic review of nutrition screening and assessment in inflammatory bowel disease.World journal of gastroenterology · 2019Pooled it
- Implementation of the glim criteria for malnutrition in inflammatory bowel diseases: a scoping review.European journal of clinical nutrition · 2026Article
- Optimizing Malnutrition Risk Detection in Inflammatory Bowel Disease: A Longitudinal Analysis of Serial Nutritional Screening Tools.Nutrients · 2026Article
- Protein-Calorie Malnutrition Is Associated with Altered Colonic Mucosal Microbiota in Inflammatory Bowel Disease.Nutrients · 2025Article
- Review
- Article
- Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture.Frontiers in immunology · 2024Article
- Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study.Journal of cachexia, sarcopenia and muscle · 2023Observational
- Review
- Nutritional status in perianal Crohn's disease: are we underestimating the impact?Frontiers in nutrition · 2023Review
- Nutritional screening and assessment in inflammatory bowel disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Review
- Outcomes of Pediatric Patients with Crohn's Disease Received Infliximab or Exclusive Enteral Nutrition during Induction Remission.Gastroenterology research and practice · 2022Article
- Role of Human Body Composition Analysis and Malnutrition Risk Questionnaire in the Assessment of Nutritional Status of Patients With Initially Diagnosed Crohn's Disease.Frontiers in medicine · 2020Article
- Adherence to an elemental diet for preventing postoperative recurrence of Crohn's disease.Surgery today · 2017Article
- The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer.Surgery today · 2017Article
- Nutritional Strategies in the Management of Adult Patients with Inflammatory Bowel Disease: Dietary Considerations from Active Disease to Disease Remission.Current gastroenterology reports · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCrohn's disease (CD) is a refractory inflammatory bowel disease of unknown etiology, frequently complicated by malnutrition. It is thought that the delayed wound healing associated with this malnutrition in CD patients might adversely affect the therapeutic benefits of infliximab (IFX). Therefore, we investigated the effects of nutritional status on IFX treatment.
methodsWe assessed nutritional status and CD activity when IFX therapy was initiated and following the third dose, 6 weeks later. Nutritional status was assessed using the body mass index (BMI) and nutritional risk index (NRI), whereas CD activity was assessed using the CD activity index (CDAI).
resultsAll patients with a BMI ≥ 18.5 kg/m(2) at the time of IFX therapy met the effective criteria for the CDAI, and IFX treatment was considered responsive in these patients. Furthermore, IFX treatment was responsive, with a high level of effectiveness, in all five subjects (31.3 %) with NRI scores of 97.5 and above with no risk of malnutrition (p = 0.037).
conclusionsOur results suggest that nutritional status does influence the therapeutic effect of IFX in CD patients. The response rate to IFX treatment thus could be improved by optimizing the nutritional status. We recommend comprehensive nutritional assessment and intervention prior to IFX treatment schedules.
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