ArticleEuropean journal of applied physiology2015
Hypovolemic men and women regulate blood pressure differently following exposure to artificial gravity.
Article in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Acute Effects of Whole-Body Vibration on Peripheral Blood Flow, Vibrotactile Perception and Balance in Older Adults.International journal of environmental research and public health · 2020Trial
- Dose-dependent effects of graded altered gravity during hypovolaemia on central haemodynamics and cardiovascular autonomic regulation.Experimental physiology · 2026Article
- Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies.NPJ microgravity · 2026Article
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- Internal jugular venous flow responses to graded lower body negative pressure: a sex-stratified analysis.Frontiers in physiology · 2026Article
- A combined individualized cycling exercise and artificial gravity training protocol as a spaceflight deconditioning countermeasure.NPJ microgravity · 2025Article
- Repeatability of artificial gravity tolerance times.Frontiers in physiology · 2025Article
- Association of gender with cardiovascular and autonomic responses to central hypovolemia.Frontiers in cardiovascular medicine · 2023Article
- Computational modeling of orthostatic intolerance for travel to Mars.NPJ microgravity · 2022Article
- Gravity Threshold and Dose Response Relationships: Health Benefits Using a Short Arm Human Centrifuge.Frontiers in physiology · 2021Article
- Coagulation Changes during Central Hypovolemia across Seasons.Journal of clinical medicine · 2020Article
- Effect of novel short-arm human centrifugation-induced gravitational gradients upon cardiovascular responses, cerebral perfusion and g-tolerance.The Journal of physiology · 2020Article
- Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization.Scientific reports · 2020Article
- The effects of varying gravito-inertial stressors on grip strength and hemodynamic responses in men and women.European journal of applied physiology · 2019Article
- Artificial Gravity as a Countermeasure to the Cardiovascular Deconditioning of Spaceflight: Gender Perspectives.Frontiers in physiology · 2018Review
- Gender-Specific Cardiovascular Reactions to +Gz Interval Training on a Short Arm Human Centrifuge.Frontiers in physiology · 2018Article
- Gender differences in tibial microvascular flow responses to head down tilt and lower body negative pressure.Physiological reports · 2017Article
- Centrifugation as a countermeasure during bed rest and dry immersion: What has been learned?Journal of musculoskeletal & neuronal interactions · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn addition to serious bone, vestibular, and muscle deterioration, space flight leads to cardiovascular dysfunction upon return to gravity. In seeking a countermeasure to space flight-induced orthostatic intolerance, we previously determined that exposure to artificial gravity (AG) training in a centrifuge improved orthostatic tolerance of ambulatory subjects. This protocol was more effective in men than women and more effective when subjects exercised.
methodsWe now determine the orthostatic tolerance limit (OTL) of cardiovascularly deconditioned (furosemide) men and women on one day following 90 min of AG compared to a control day (90 min of head-down bed rest, HDBR).
resultsThere were three major findings: a short bout of artificial gravity improved orthostatic tolerance of hypovolemic men (30 %) and women (22 %). Men and women demonstrated different mechanisms of cardiovascular regulation on AG and HDBR days; women maintained systolic blood pressure the same after HDBR and AG exposure while men's systolic pressure dropped (11 ± 2.9 mmHg) after AG. Third, as presyncopal symptoms developed, men's and women's cardiac output and stroke volume dropped to the same level on both days, even though the OTL test lasted significantly longer on the AG day, indicating cardiac filling as a likely variable to trigger presyncope.
conclusions(1) Even with gender differences, AG should be considered as a space flight countermeasure to be applied to astronauts before reentry into gravity, (2) men and women regulate blood pressure during an orthostatic stress differently following exposure to artificial gravity and (3) the trigger for presyncope may be cardiac filling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.