ArticleGenome biology2015
Standing genetic variation as a major contributor to adaptation in the Virginia chicken lines selection experiment.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Origins of adaptive genomic variation in a wild rodent.Communications biology · 2026Article
- An ancient origin of the naked grains of maize.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adaptive colonization across a parasitism-mutualism gradient.Evolution letters · 2024Article
- Article
- Research Note: Phenotypic trends for the multigenerational advanced intercross of the Virginia body weight lines of chickens.Poultry science · 2024Article
- Analysis of adaptive molecular mechanisms in response to low salinity in antennal gland of mud crab,Heliyon · 2024Article
- Rapid genomic evolution in Brassica rapa with bumblebee selection in experimental evolution.BMC ecology and evolution · 2024Article
- Article
- Genetic Variance Estimation over Time in Broiler Breeding Programmes for Growth and Reproductive Traits.Animals : an open access journal from MDPI · 2023Article
- Genome-wide mapping of signatures of selection using a high-density array identified candidate genes for growth traits and local adaptation in chickens.Genetics, selection, evolution : GSE · 2023Article
- Assessment the effect of genomic selection and detection of selective signature in broilers.Poultry science · 2022Article
- Article
- Dynamics of Small Non-coding RNA Profiles and the Intestinal Microbiome of High and Low Weight Chickens.Frontiers in microbiology · 2022Article
- Genome‑wide association study and genomic prediction for growth traits in yellow-plumage chicken using genotyping-by-sequencing.Genetics, selection, evolution : GSE · 2021Article
- Microevolutionary Dynamics of Chicken Genomes under Divergent Selection for Adiposity.iScience · 2020Article
- Article
- Dynamic genetic architecture of yeast response to environmental perturbation shed light on origin of cryptic genetic variation.PLoS genetics · 2020Article
- Accurate Allele Frequencies from Ultra-low Coverage Pool-Seq Samples in Evolve-and-Resequence Experiments.G3 (Bethesda, Md.) · 2019Article
- A genomic inference of the White Plymouth Rock genealogy.Poultry science · 2019Article
- Adaptation in structured populations and fuzzy boundaries between hard and soft sweeps.PLoS computational biology · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundArtificial selection provides a powerful approach to study the genetics of adaptation. Using selective-sweep mapping, it is possible to identify genomic regions where allele-frequencies have diverged during selection. To avoid false positive signatures of selection, it is necessary to show that a sweep affects a selected trait before it can be considered adaptive. Here, we confirm candidate, genome-wide distributed selective sweeps originating from the standing genetic variation in a long-term selection experiment on high and low body weight of chickens.
resultsUsing an intercross between the two divergent chicken lines, 16 adaptive selective sweeps were confirmed based on their association with the body weight at 56 days of age. Although individual additive effects were small, the fixation for alternative alleles across the loci contributed at least 40 % of the phenotypic difference for the selected trait between these lines. The sweeps contributed about half of the additive genetic variance present within and between the lines after 40 generations of selection, corresponding to a considerable portion of the additive genetic variance of the base population.
conclusionsLong-term, single-trait, bi-directional selection in the Virginia chicken lines has resulted in a gradual response to selection for extreme phenotypes without a drastic reduction in the genetic variation. We find that fixation of several standing genetic variants across a highly polygenic genetic architecture made a considerable contribution to long-term selection response. This provides new fundamental insights into the dynamics of standing genetic variation during long-term selection and adaptation.
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