ArticleNature communications2015
Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET).Science advances · 2026Article
- Advances in ligand-based surface engineering strategies for fine-tuning T cell mechanotransduction toward efficient immunotherapy.Biophysical journal · 2025Review
- Leaflet-Specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers.Angewandte Chemie (International ed. in English) · 2025Article
- Active membrane deformations of a minimal synthetic cell.Nature physics · 2025Article
- Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy.Communications biology · 2024Article
- Measuring sub-nanometer undulations at microsecond temporal resolution with metal- and graphene-induced energy transfer spectroscopy.Nature communications · 2024Article
- Comparison of thermal and athermal dynamics of the cell membrane slope fluctuations in the presence and absence of Latrunculin-B.Physical biology · 2023Article
- The interplay between membrane topology and mechanical forces in regulating T cell receptor activity.Communications biology · 2022Review
- Integrin-Functionalised Giant Unilamellar Vesicles via Gel-Assisted Formation: Good Practices and Pitfalls.International journal of molecular sciences · 2021Article
- Digital holographic microscopy evaluation of dynamic cell response to electroporation.Biomedical optics express · 2021Article
- Delivery of the RadionuclideInternational journal of molecular sciences · 2021Article
- Large-scale simulation of biomembranes incorporating realistic kinetics into coarse-grained models.Nature communications · 2020Article
- Statistical Mechanics of an Elastically Pinned Membrane: Equilibrium Dynamics and Power Spectrum.Biophysical journal · 2019Article
- Plasmonic imaging of subcellular electromechanical deformation in mammalian cells.Journal of biomedical optics · 2019Article
- Cholesterol Depletion by MβCD Enhances Cell Membrane Tension and Its Variations-Reducing Integrity.Biophysical journal · 2019Article
- Membrane fluctuations and acidosis regulate cooperative binding of 'marker of self' protein CD47 with the macrophage checkpoint receptor SIRPα.Journal of cell science · 2018Article
- Tracking fast cellular membrane dynamics with sub-nm accuracy in the normal direction.Nanoscale · 2018Article
- Article
- High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.Frontiers in immunology · 2018Article
- Mapping Cell Membrane Fluctuations Reveals Their Active Regulation and Transient Heterogeneities.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Stochastic displacements or fluctuations of biological membranes are increasingly recognized as an important aspect of many physiological processes, but hitherto their precise quantification in living cells was limited due to a lack of tools to accurately record them. Here we introduce a novel technique--dynamic optical displacement spectroscopy (DODS), to measure stochastic displacements of membranes with unprecedented combined spatiotemporal resolution of 20 nm and 10 μs. The technique was validated by measuring bending fluctuations of model membranes. DODS was then used to explore the fluctuations in human red blood cells, which showed an ATP-induced enhancement of non-Gaussian behaviour. Plasma membrane fluctuations of human macrophages were quantified to this accuracy for the first time. Stimulation with a cytokine enhanced non-Gaussian contributions to these fluctuations. Simplicity of implementation, and high accuracy make DODS a promising tool for comprehensive understanding of stochastic membrane processes.
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