ArticleLeukemia2016
A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros.
Open access · bronzeAbstract readLetter
In one paragraph
Article in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia.Leukemia · 2022Pooled it
- Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2023Review
- Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children.Leukemia · 2022Review
- Variant to function mapping at single-cell resolution through network propagation.Nature biotechnology · 2022Article
- An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis.Nature communications · 2022Article
- Variant to function mapping at single-cell resolution through network propagation.bioRxiv : the preprint server for biology · 2022Article
- Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges.Frontiers in cell and developmental biology · 2021Article
- B-ALL Complexity: Is Targeted Therapy Still A Valuable Approach for Pediatric Patients?Cancers · 2020Review
- Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.Genes, chromosomes & cancer · 2019Article
- Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism.Leukemia · 2019Article
- BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.International journal of cancer · 2018Article
- A causal mechanism for childhood acute lymphoblastic leukaemia.Nature reviews. Cancer · 2018Review
- An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016.Pediatric hematology and oncology · 2018Article
- GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21.Nature communications · 2018Article
- Genetic susceptibility in childhood acute lymphoblastic leukemia.Medical oncology (Northwood, London, England) · 2017Review
- Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.Human molecular genetics · 2017Article
- C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells.Stem cell reports · 2017Article
- Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.Oncotarget · 2016Article
- Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.Oncotarget · 2016Article
- Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.Carcinogenesis · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
J L WiemelsDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
A J de SmithDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
J XiaoDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
S-T LeeDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
M O MuenchDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
M E FominBlood Systems Research Institute and Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
M ZhouDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
H M HansenDivision of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
A TermuhlenJonathan Jaques Children's Cancer Center, Department of Pediatrics, Keck School of Medicine, University of South California, Long Beach, CA, USA.
C MetayerSchool of Public Health, University of California Berkeley, Berkeley, CA, USA.
K M WalshDivision of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USYonsei University · KRBerkeley Public Health Division · USChildren's Cancer Center · USNeurological Surgery · US
Funding
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1MTraining in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5MReprogramming iPS Cells with Exogenous and Endogenous Transcription Factor GenesP01DK088760 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRUENERT, DIETER C · 2011 to 2015
$6.5MGenome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1MProject 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7MNCI NIH HHS R01 CA155461NCI NIH HHS R25 CA112355NIDDK NIH HHS P01 DK088760NIEHS NIH HHS P01 ES018172NIEHS NIH HHS R01 ES009137
Abstract
PubMed holds no abstract for this paper.
Indexed as
Genetic Predisposition to DiseasePolymorphism, Single NucleotidePromoter Regions, GeneticCCAAT-Enhancer-Binding ProteinsChromosomes, Human, Pair 14Genome-Wide Association StudyHumansIkaros Transcription FactorPrecursor Cell Lymphoblastic Leukemia-LymphomaCCAAT-Enhancer-Binding ProteinsCEBPE protein, humanIkaros Transcription FactorIKZF1 protein, human
Identifiers
What OpenQuestion holds
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.