ArticleThe Journal of physiology2015
Impact of sympathetic nervous system activity on post-exercise flow-mediated dilatation in humans.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04371757 (Influence of the Autonomic Nervous System on Endothelial Function as an Acute Response to Exercise in Hypertensive Individuals), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of the Autonomic Nervous System on Endothelial Function as an Acute Response to Exercise in Hypertensive Individuals: a Randomized Double-blind Protocol Study
Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Post-isometric exercise hypotension occurs irrespective of muscle mass in adults with hypertension: A randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2025Trial
- Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial.Scientific reports · 2021Trial
- UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- The effect of αThe Journal of physiology · 2017Trial
- Resistance-based interval exercise acutely improves endothelial function in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Trial
- Vascular and autonomic recovery after resistance training with and without post-exercise static stretching: a randomized controlled crossover trial.European journal of applied physiology · 2026Article
- Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis.Experimental physiology · 2026Article
- Oxidative stress and impaired cardiovagal baroreflex sensitivity in young adults with post-traumatic stress disorder.Experimental physiology · 2026Article
- A single bout of submaximal aerobic functional capacity test acutely promotes endothelial function in long COVID patients.Scientific reports · 2026Article
- Optimizing cerebrovascular endothelial health through shear stress modulation.Experimental physiology · 2025Review
- Effects of interval versus continuous exercise on cerebral vascular flow-mediated dilatation in young healthy males.Physiological reports · 2025Article
- Circulating catecholamines, endothelin-1, and nitric oxide releases do not explain the preserved FMD following acute resistance exercise in strength-trained men.European journal of applied physiology · 2024Article
- Acute Effects of Combining Weight and Elastic Resistance Exercise on Vascular Function in Older Adults.Geriatrics (Basel, Switzerland) · 2024Article
- Increasing pulse pressure ex vivo, mimicking acute physical exercise, induces smooth muscle cell-mediated de-stiffening of murine aortic segments.Communications biology · 2023Article
- Handgrip exercise does not alter COExperimental physiology · 2023Article
- Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults.European journal of applied physiology · 2023Article
- The acute effect of heat exposure on forearm macro- and microvascular function: Impact of measurement timing, heating modality and biological sex.Experimental physiology · 2023Article
- Impact of acute dynamic exercise and arterial shear rate modification on radial artery low-flow mediated constriction in young men.European journal of applied physiology · 2022Article
- High-but not moderate-intensity exercise acutely attenuates hypercapnia-induced vasodilation of the internal carotid artery in young men.European journal of applied physiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient reduction in vascular function following systemic large muscle group exercise has previously been reported in humans. The mechanisms responsible are currently unknown. We hypothesised that sympathetic nervous system activation, induced by cycle ergometer exercise, would contribute to post-exercise reductions in flow-mediated dilatation (FMD). Ten healthy male subjects (28 ± 5 years) undertook two 30 min sessions of cycle exercise at 75% HR(max). Prior to exercise, individuals ingested either a placebo or an α1-adrenoreceptor blocker (prazosin; 0.05 mg kg(-1)). Central haemodynamics, brachial artery shear rate (SR) and blood flow profiles were assessed throughout each exercise bout and in response to brachial artery FMD, measured prior to, immediately after and 60 min after exercise. Cycle exercise increased both mean and antegrade SR (P < 0.001) with retrograde SR also elevated under both conditions (P < 0.001). Pre-exercise FMD was similar on both occasions, and was significantly reduced (27%) immediately following exercise in the placebo condition (t-test, P = 0.03). In contrast, FMD increased (37%) immediately following exercise in the prazosin condition (t-test, P = 0.004, interaction effect P = 0.01). Post-exercise FMD remained different between conditions after correction for baseline diameters preceding cuff deflation and also post-deflation SR. No differences in FMD or other variables were evident 60 min following recovery. Our results indicate that sympathetic vasoconstriction competes with endothelium-dependent dilator activity to determine post-exercise arterial function. These findings have implications for understanding the chronic impacts of interventions, such as exercise training, which affect both sympathetic activity and arterial shear stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.