ArticleClinical and experimental immunology2016
Evaluation of a novel automated allergy microarray platform compared with three other allergy test methods.
Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Microarray Analysis Confirms ImmunoCAP-Fluorescence Enzyme Immunoassay Results on Specific IgE in Patients with Atopic Dermatitis and Suspected Birch Pollen-Related Food Allergy.International archives of allergy and immunology · 2022Trial
- From skin testing to molecular diagnostics: the precision leap in dust mite allergy diagnosis and clinical translation challenges.Frontiers in allergy · 2025Review
- Protein Biochips with Three-Dimensional Hydrogel or Polymer Brush Elements for the Detection of Human Serum Immunoglobulin E Specific to Inhalation Allergens.International journal of molecular sciences · 2024Article
- Microarray-based evaluation of selected recombinant timothy grass allergens expressed in E. Coli and N. Benthamiana.BMC biotechnology · 2024Article
- Allergen Microarrays and New Physical Approaches to More Sensitive and Specific Detection of Allergen-Specific Antibodies.Biosensors · 2024Review
- The use of microarray and other multiplex technologies in the diagnosis of allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Review
- Allergic sensitization during early life: Concordance between ImmunoCAP and ISAC results.The journal of allergy and clinical immunology. In practice · 2021Article
- A WAO - ARIA - GAThe World Allergy Organization journal · 2020Article
- IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.The World Allergy Organization journal · 2020Article
- Microarray Immunodiagnostics for Aeroallergens.Current allergy and asthma reports · 2019Review
- Precision medicine allergy immunoassay methods for assessing immunoglobulin E sensitization to aeroallergen molecules.World journal of methodology · 2018Article
- Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study.The World Allergy Organization journal · 2018Article
- Microarray Technology Applied to Human Allergic Disease.Microarrays (Basel, Switzerland) · 2017Review
- Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future.The World Allergy Organization journal · 2017Article
- Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy.Clinical and translational allergy · 2017Article
- Comparison and clinical utility evaluation of four multiple allergen simultaneous tests including two newly introduced fully automated analyzers.Practical laboratory medicine · 2016Article
- Pilot study: assessing the clinical diagnosis of allergy in atopic children using a microarray assay in addition to skin prick testing and serum specific IgE.Clinical and molecular allergy : CMA · 2016Article
- Using Component-Resolved Diagnostics in the Management of Peanut-Allergic Patients.Current treatment options in allergyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microarray platforms, enabling simultaneous measurement of many allergens with a small serum sample, are potentially powerful tools in allergy diagnostics. We report here the first study comparing a fully automated microarray system, the Microtest allergy system, with a manual microarray platform, Immuno-Solid phase Allergen Chip (ISAC), and two well-established singleplex allergy tests, skin prick test (SPT) and ImmunoCAP, all tested on the same patients. One hundred and three adult allergic patients attending the allergy clinic were included into the study. All patients were tested with four allergy test methods (SPT, ImmunoCAP, Microtest and ISAC 112) and a total of 3485 pairwise test results were analysed and compared. The four methods showed comparable results with a positive/negative agreement of 81-88% for any pair of test methods compared, which is in line with data in the literature. The most prevalent allergens (cat, dog, mite, timothy, birch and peanut) and their individual allergen components revealed an agreement between methods with correlation coefficients between 0·73 and 0·95. All four methods revealed deviating individual patient results for a minority of patients. These results indicate that microarray platforms are efficient and useful tools to characterize the specific immunoglobulin (Ig)E profile of allergic patients using a small volume of serum sample. The results produced by the Microtest system were in agreement with diagnostic tests in current use. Further data collection and evaluation are needed for other populations, geographical regions and allergens.
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