ArticleParasitology research2016
Are commercial probiotics and prebiotics effective in the treatment and prevention of honeybee nosemosis C?
Article in Parasitology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Nosemosis negatively affects honeybee survival: experimental and meta-analytic evidence.Parasitology · 2024Pooled it
- In Vivo and In Vitro Evaluation of Probiotic and Postbiotic Strategies Against Foulbrood in Honeybees.Probiotics and antimicrobial proteins · 2026Article
- Impact of Direct-Fed Microorganism Syrup on Honey Bee (Animals : an open access journal from MDPI · 2026Article
- Exploring Eco-Friendly Microbial Strategies for Nosemosis Control in Honeybee.Microorganisms · 2025Review
- Lactic Acid Bacteria: A Probiotic to Mitigate Pesticide Stress in Honey Bee.Probiotics and antimicrobial proteins · 2025Review
- Isolation and probiotic evaluation of Apilactobacillus kunkeei and Bombella sp. from Apis mellifera anatoliaca and Bombus terrestris.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- A Review of Diet and Foraged Pollen Interactions with the Honeybee Gut Microbiome.Microbial ecology · 2025Review
- Probiotic Potential of Bacillus Subtilis Strain I3: Antagonistic Activity Against Chalkbrood Pathogen and Pesticide Degradation for Enhancing Honeybee Health.Probiotics and antimicrobial proteins · 2025Article
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- Honeybee gut bacterial strain improved survival and gut microbiota homeostasis inMicrobiology spectrum · 2024Article
- How does adulteration of wax foundation affect phenoloxidase and lysozyme activities as selected parameters of immunity inJournal of veterinary research · 2024Article
- Effects of a supplemented diet containing 7 probiotic strains (Honeybeeotic) on honeybee physiology and immune response: analysis of hemolymph cytology, phenoloxidase activity, and gut microbiome.Biological research · 2024Article
- Evaluation of Functional Properties of Some Lactic Acid Bacteria Strains for Probiotic Applications in Apiculture.Microorganisms · 2024Article
- Prospects of probiotics in beekeeping: a review for sustainable approach to boost honeybee health.Archives of microbiology · 2024Review
- Probiotics and in-hive fermentation as a source of beneficial microbes to support the gut microbial health of honey bees.Journal of insect science (Online) · 2023Review
- Delivery mechanism can enhance probiotic activity against honey bee pathogens.The ISME journal · 2023Article
- Biocontrol potential of Apilactobacillus kunkeei EIR/BG-1 against infectious diseases in honey bees (Apis mellifera L.).Veterinary research communications · 2023Article
- Characterization and Protective Properties of Lactic Acid Bacteria Intended to Be Used in Probiotic Preparation for Honeybees (Animals : an open access journal from MDPI · 2023Article
- Beneficial bacteria as biocontrol agents for American foulbrood disease in honey bees (Apis mellifera).Journal of insect science (Online) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study was conducted to investigate the effect of Lactobacillus rhamnosus (a commercial probiotic) and inulin (a prebiotic) on the survival rates of honeybees infected and uninfected with Nosema ceranae, the level of phenoloxidase (PO) activity, the course of nosemosis, and the effect on the prevention of nosemosis development in bees. The cells of L. rhamnosus exhibited a high rate of survival in 56.56 % sugar syrup, which was used to feed the honeybees. Surprisingly, honeybees fed with sugar syrup supplemented with a commercial probiotic and a probiotic + prebiotic were more susceptible to N. ceranae infection, and their lifespan was much shorter. The number of microsporidian spores in the honeybees fed for 9 days prior to N. ceranae infection with a sugar syrup supplemented with a commercial probiotic was 25 times higher (970 million spores per one honeybee) than in a control group fed with pure sucrose syrup (38 million spores per one honeybee). PO activity reached its highest level in the hemolymph of this honeybee control group uninfected with N. ceranae. The addition of probiotics or both probiotics and prebiotics to the food of uninfected bees led to the ~2-fold decrease in the PO activity. The infection of honeybees with N. ceranae accompanied an almost 20-fold decrease in the PO level. The inulin supplemented solely at a concentration of 2 μg/mL was the only administrated factor which did not significantly affect honeybees' survival, the PO activity, or the nosemosis infection level. In conclusion, the supplementation of honeybees' diet with improperly selected probiotics or both probiotics and prebiotics does not prevent nosemosis development, can de-regulate insect immune systems, and may significantly increase bee mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.