ArticleThe Science of the total environment2016
Environmental exposure to manganese in air: Associations with tremor and motor function.
Article in The Science of the total environment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Impact of Environmental Airborne Manganese Exposure on Cognitive and Motor Functions in Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Tamoxifen induces partial neuroprotection against manganese toxicity in the dopaminergic REST-deleted male mice.Neurotoxicology · 2025Article
- Article
- Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17β-estradiol afforded protection against this manganese toxicity.Neurotoxicology · 2024Article
- Child and Adolescent Manganese Biomarkers and Adolescent Postural Balance in Marietta CARES Cohort Participants.Environmental health perspectives · 2024Article
- Role of Macrophages in Air Pollution Exposure Related Asthma.International journal of molecular sciences · 2022Review
- Validation of in vivo toenail measurements of manganese and mercury using a portable X-ray fluorescence device.Journal of exposure science & environmental epidemiology · 2022Article
- The association of bone and blood manganese with motor function in Chinese workers.Neurotoxicology · 2022Article
- Physicochemical Properties of Indoor and Outdoor Particulate Matter 2.5 in Selected Residential Areas near a Ferromanganese Smelter.International journal of environmental research and public health · 2021Article
- Depression and anxiety in a manganese-exposed community.Neurotoxicology · 2021Article
- Evaluating the risk of manganese-induced neurotoxicity of parenteral nutrition: review of the current literature.Expert opinion on drug metabolism & toxicology · 2021Review
- Severity of parkinsonism associated with environmental manganese exposure.Environmental health : a global access science source · 2021Article
- Tridimensional spatial distribution of manganese in a river impacted by metallurgical activity and mining.Environmental science and pollution research international · 2021Article
- A Rapid Motor Task-Based Screening Tool for Parkinsonism in Community-Based Studies.Frontiers in neurology · 2021Article
- Manganese Exposure and Neurologic Outcomes in Adult Populations.Neurologic clinics · 2020Review
- The effects of manganese overexposure on brain health.Neurochemistry international · 2020Review
- Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats.International journal of environmental research and public health · 2019Article
- Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles.Neurotoxicology · 2018Article
- Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration.Frontiers in aging neuroscience · 2018Review
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundManganese (Mn) inhalation has been associated with neuropsychological and neurological sequelae in exposed workers. Few environmental epidemiologic studies have examined the potentially neurotoxic effects of Mn exposure in ambient air on motor function and hand tremor in adult community residents. Mn exposed residents were recruited in two Ohio towns: Marietta, a town near a ferro-manganese smelter, and East Liverpool, a town adjacent to a facility processing, crushing, screening, and packaging Mn products.
methodsChronic (≥ 10 years) exposure to ambient air Mn in adult residents and effects on neuropsychological and neurological outcomes were investigated. Participants from Marietta (n=100) and East Liverpool (n=86) were combined for analyses. AERMOD dispersion modeling of fixed-site outdoor air monitoring data estimated Mn inhalation over a ten year period. Adult Mn-exposed residents' psychomotor ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian structural equation modeling was used to assess associations between air-Mn and motor function and tremor.
resultsAir-Mn exposure was significantly correlated in bivariate analyses with the tremor test (CATSYS) for intensity, center frequency and harmonic index. The Bayesian path analysis model showed associations of air-Mn with the CATSYS non-dominant center frequency and harmonic index; while the Bayesian structural equation model revealed associations between air-Mn and lower Finger Tapping scores. Household income was significantly associated with motor dysfunction but not with tremor.
conclusionTremor and motor function were associated with higher exposure to airborne Mn.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.