ArticleNature immunology2015
Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.
Article in Nature immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Non-Canonical Compartmentalization of DROSHA Protein at the Golgi Apparatus: miRNA Biogenesis-Independent Functionality in Human Cancer Cells of Diverse Tissue Origin.International journal of molecular sciences · 2025Article
- Regulation of the microprocessor by post-translational modifications.Frontiers in cell and developmental biology · 2025Review
- Non-canonical RNA substrates of Drosha lack many of the conserved features found in primary microRNA stem-loops.Scientific reports · 2024Article
- MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine.PloS one · 2022Article
- DROSHA but not DICER is required for human haematopoietic stem cell function.Clinical & translational immunology · 2022Article
- DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.Life science alliance · 2021Article
- Modulators of MicroRNA Function in the Immune System.International journal of molecular sciences · 2020Review
- Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo.Cellular and molecular life sciences : CMLS · 2019Review
- Article
- Review
- Adenosine methylation as a molecular imprint defining the fate of RNA.FEBS letters · 2018Review
- From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.Chemical reviews · 2018Review
- Emerging roles of DROSHA beyond primary microRNA processing.RNA biology · 2018Article
- Non-canonical post-transcriptional RNA regulation of neural stem cell potential.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- IL4 and IL21 cooperate to induce the high Bcl6 protein level required for germinal center formation.Immunology and cell biology · 2017Article
- A novel requirement for DROSHA in maintenance of mammalian CG methylation.Nucleic acids research · 2017Article
- DROSHA targets its own transcript to modulate alternative splicing.RNA (New York, N.Y.) · 2017Article
- RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.Nature structural & molecular biology · 2017Article
- Cytoplasmic Drosha activity generated by alternative splicing.Nucleic acids research · 2016Article
- Cellular and molecular regulation of innate inflammatory responses.Cellular & molecular immunology · 2016Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate if the microRNA (miRNA) pathway is required for dendritic cell (DC) development, we assessed the effect of ablating Drosha and Dicer, the two enzymes central to miRNA biogenesis. We found that while Dicer deficiency had some effect, Drosha deficiency completely halted DC development and halted myelopoiesis more generally. This indicated that while the miRNA pathway did have a role, it was a non-miRNA function of Drosha that was particularly critical. Drosha repressed the expression of two mRNAs encoding inhibitors of myelopoiesis in early hematopoietic progenitors. We found that Drosha directly cleaved stem-loop structure within these mRNAs and that this mRNA degradation was necessary for myelopoiesis. We have therefore identified a mechanism that regulates the development of DCs and other myeloid cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.