ArticleVirology2015
A systems approach to understanding human rhinovirus and influenza virus infection.
Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Virus-Induced Cellular Senescence Causes Pulmonary Sequelae Post-Influenza Infection.Aging cell · 2025Article
- Bronchial smooth muscle extracellular vesicles interfere with bronchial epithelium metabolism and function in asthma.iScience · 2025Article
- Article
- Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells.Scientific reports · 2021Article
- Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study.Allergy · 2020Article
- Comparative Transcriptomic Analysis of Rhinovirus and Influenza Virus Infection.Frontiers in microbiology · 2020Article
- Plasmin Cascade Mediates Thrombotic Events in SARS-CoV-2 Infection via Complement and Platelet-Activating Systems.IEEE open journal of engineering in medicine and biology · 2020Article
- Dynamically characterizing individual clinical change by the steady state of disease-associated pathway.BMC bioinformatics · 2019Article
- Respiratory epithelial cells as master communicators during viral infections.Current clinical microbiology reports · 2019Article
- Despite AntagonismFrontiers in microbiology · 2019Article
- Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets.Systems medicine (New Rochelle, N.Y.) · 2019Article
- Effects of intranasal administration withExperimental and therapeutic medicine · 2018Article
- Construction of a Transcriptome-Driven Network at the Early Stage of Infection with Influenza A H1N1 in Human Lung Alveolar Epithelial Cells.Biomolecules & therapeutics · 2018Article
- Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses.PloS one · 2017Article
- Respiratory viral infections and host responses; insights from genomics.Respiratory research · 2016Review
- Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human rhinovirus and influenza virus infections of the upper airway lead to colds and the flu and can trigger exacerbations of lower airway diseases including asthma and chronic obstructive pulmonary disease. Novel diagnostic and therapeutic targets are still needed to differentiate between the cold and the flu, since the clinical course of influenza can be severe while that of rhinovirus is usually more mild. In our investigation of influenza and rhinovirus infection of human respiratory epithelial cells, we used a systems approach to identify the temporally changing patterns of host gene expression from these viruses. After infection of human bronchial epithelial cells (BEAS-2B) with rhinovirus, influenza virus or co-infection with both viruses, we studied the time-course of host gene expression changes over three days. We modeled host responses to these viral infections with time and documented the qualitative and quantitative differences in innate immune activation and regulation.
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