Evidence map›Paper›PMID 26437175›Full record

ArticleNature communications2015

Brightness-equalized quantum dots.

Sung Jun Lim, Mohammad U Zahid, Phuong Le, Liang Ma, David Entenberg, Allison S Harney, John Condeelis, Andrew M Smith

Abstract read
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
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  12. Direct Patterning of CsPbBrACS applied energy materials · 2022
    Article
  13. Article
  14. Article
  15. Antibody Self-Assembly Maximizes Cytoplasmic Immunostaining Accuracy of Compact Quantum Dots.Chemistry of materials : a publication of the American Chemical Society · 2021
    Article
  16. Article
  17. Engineering Brightness Matched Indium Phosphide Quantum Dots.Chemistry of materials : a publication of the American Chemical Society · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sung Jun LimDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Mohammad U ZahidDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Phuong LeDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Liang MaMicro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
David EntenbergDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
Allison S HarneyDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
John CondeelisDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.
Andrew M SmithDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
Tumor Progression and MetastasisP01CA100324 · NCI · YESHIVA UNIVERSITY · PI CONDEELIS, JOHN S · 2003 to 2018
$30.0M
Next-Generation Quantum Dots for Molecular and Cellular Imaging of CancerR00CA153914 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SMITH, ANDREW MICHAEL · 2012 to 2014
$709k
NCI NIH HHS P01 CA100324NCI NIH HHS P30 CA013330NCI NIH HHS R00 CA153914NCI NIH HHS R00CA153914
6 · The paper itself

Abstract

As molecular labels for cells and tissues, fluorescent probes have shaped our understanding of biological structures and processes. However, their capacity for quantitative analysis is limited because photon emission rates from multicolour fluorophores are dissimilar, unstable and often unpredictable, which obscures correlations between measured fluorescence and molecular concentration. Here we introduce a new class of light-emitting quantum dots with tunable and equalized fluorescence brightness across a broad range of colours. The key feature is independent tunability of emission wavelength, extinction coefficient and quantum yield through distinct structural domains in the nanocrystal. Precise tuning eliminates a 100-fold red-to-green brightness mismatch of size-tuned quantum dots at the ensemble and single-particle levels, which substantially improves quantitative imaging accuracy in biological tissue. We anticipate that these materials engineering principles will vastly expand the optical engineering landscape of fluorescent probes, facilitate quantitative multicolour imaging in living tissue and improve colour tuning in light-emitting devices.

Indexed as

NanoparticlesOptical ImagingQuantum DotsAnimalsFemaleMiceMice, TransgenicMicroscopy, Electron, TransmissionMicroscopy, Fluorescence, MultiphotonNanotechnologySpectrometry, Fluorescence

Identifiers

PMID26437175
PMCPMC4594210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.