Evidence map›Paper›PMID 26436900›Full record

ArticleNature neuroscience2015

Human mutant huntingtin disrupts vocal learning in transgenic songbirds.

Wan-Chun Liu, Jessica Kohn, Sarah K Szwed, Eben Pariser, Sharon Sepe, Bhagwattie Haripal, Naoki Oshimori, Martin Marsala, Atsushi Miyanohara, Ramee Lee

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  7. Article
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  9. Article
  10. Article
  11. Review
  12. Avian genomics lends insights into endocrine function in birds.General and comparative endocrinology · 2018
    Review
  13. Primordial germ cell-mediated transgenesis and genome editing in birds.Journal of animal science and biotechnology · 2018
    Review
  14. To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017
    Review
  15. Gene editing in birds takes flight.Mammalian genome : official journal of the International Mammalian Genome Society · 2017
    Review
  16. Review
  17. Article
  18. Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wan-Chun LiuLaboratory of Animal Behavior, The Rockefeller University, New York, New York, USA.
Jessica KohnLaboratory of Animal Behavior, The Rockefeller University, New York, New York, USA.
Sarah K SzwedLaboratory of Animal Behavior, The Rockefeller University, New York, New York, USA.
Eben PariserLaboratory of Animal Behavior, The Rockefeller University, New York, New York, USA.
Sharon SepeLaboratory of Animal Behavior, The Rockefeller University, New York, New York, USA.
Bhagwattie HaripalLaboratory of Animal Behavior, The Rockefeller University, New York, New York, USA.
Naoki OshimoriLaboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA.
Martin MarsalaNeurodegeneration Laboratory, University of California, San Diego, La Jolla, California, USA.
Atsushi MiyanoharaVector Development Core Lab, UCSD School of Medicine, La Jolla, California, USA.
Ramee LeeCHDI Management Inc., New York, New York, USA.
Rockefeller University · USUniversity of California, San Diego · USCHDI Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Speech and vocal impairments characterize many neurological disorders. However, the neurogenetic mechanisms of these disorders are not well understood, and current animal models do not have the necessary circuitry to recapitulate vocal learning deficits. We developed germline transgenic songbirds, zebra finches (Taneiopygia guttata) expressing human mutant huntingtin (mHTT), a protein responsible for the progressive deterioration of motor and cognitive function in Huntington's disease (HD). Although generally healthy, the mutant songbirds had severe vocal disorders, including poor vocal imitation, stuttering, and progressive syntax and syllable degradation. Their song abnormalities were associated with HD-related neuropathology and dysfunction of the cortical-basal ganglia (CBG) song circuit. These transgenics are, to the best of our knowledge, the first experimentally created, functional mutant songbirds. Their progressive and quantifiable vocal disorder, combined with circuit dysfunction in the CBG song system, offers a model for genetic manipulation and the development of therapeutic strategies for CBG-related vocal and motor disorders.

Indexed as

AnimalsAnimals, Genetically ModifiedBasal GangliaFinchesHumansHuntingtin ProteinLearningNerve Tissue ProteinsNeuronsSongbirdsVocalization, AnimalHTT protein, humanHuntingtin ProteinNerve Tissue Proteins

Identifiers

PMID26436900
OpenAlexW2136852632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.