ArticleAmerican journal of respiratory cell and molecular biology2016
Immune Modulation of the T Cell Response in Asthma through Wnt10b.
Article in American journal of respiratory cell and molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- CD4Frontiers in immunology · 2025Review
- Wnt10b knockdown regulates the relative balance of adipose tissue-resident T cells and inhibits white fat deposition.Molecular biology reports · 2024Article
- Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second-generation offspring.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Pathogenesis of allergic diseases and implications for therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- The role of WNT10B in physiology and disease: A 10-year update.Frontiers in cell and developmental biology · 2023Review
- Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria.Molecular systems biology · 2022Article
- The Role of Secreted Frizzled-related Protein-1 in Allergic Asthma.American journal of respiratory cell and molecular biology · 2022Article
- Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?Frontiers in cell and developmental biology · 2020Review
- Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma.World journal of gastroenterology · 2019Review
- WNT/β-Catenin Signaling Pathway Regulating T Cell-Inflammation in the Tumor Microenvironment.Frontiers in immunology · 2019Review
- Lung Tissue Resident Memory T-Cells in the Immune Response toFrontiers in immunology · 2019Review
- Canonical and Non-Canonical Wnt Signaling in Immune Cells.Trends in immunology · 2018Review
- Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.Journal of gastroenterology · 2017Review
- The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis.Journal of immunology research · 2017Article
- Targeted inhibition of β-catenin alleviates airway inflammation and remodeling in asthmaTherapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Asthma is a chronic inflammatory disease, which is characterized by activation of CD4(+) T helper 2 cells orchestrating an allergic airway response. Whereas the role of Wnt family members in regulating T cell maintenance and maturation is established, their contribution to T cell activation in allergic asthma is not known. We hypothesized that Wnt10b plays a role in the modulation of the allergic airway response and affects T cell activation and polarization. Using an in vivo house dust mite asthma model, Wnt10b-deficient (Wnt10b(-/-)) mice were allergen-sensitized and inflammation, as well as T cell activation, was studied in vivo and in vitro. Wnt10b(-/-) mice exhibited an augmented inflammatory phenotype with an increase in eosinophils in the bronchoalveolar lavage and IL-4 and IL-13 in the lungs when compared with wild-type mice. In vitro studies confirmed an increased T helper type 2 polarization and increased T cell activation of Wnt10b(-/-) cells. Accordingly, the percentage of naive T cells was elevated by the addition of recombinant Wnt10b protein. Finally, Wnt10b(-/-) mice exhibited an increase in the percentage of effector T cells in the lungs after house dust mite sensitization, which indicated a heightened activation state, measured by an increased percentage of CD69(hi)CD11a(hi) cells. These findings suggest that Wnt10b plays an important role in regulating asthmatic airway inflammation through modification of the T cell response and is a prospective target in the disease process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.