SynthesisClinical cardiology2015
The Prognostic Significance of Right Bundle Branch Block: A Meta-analysis of Prospective Cohort Studies.
Synthesis in Clinical cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Impact of Left and Right Bundle Branch Block on Left Ventricular Systolic Function and Myocardial Mechanics Assessed by Speckle-Tracking Echocardiography and Cardiac Magnetic Resonance Feature Tracking: A Systematic Review and Meta-Analysis.Echocardiography (Mount Kisco, N.Y.) · 2026Pooled it
- The prognostic significance of bundle branch block in acute heart failure: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Pooled it
- Clinical Impact of Preexisting Right Bundle Branch Block after Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Journal of interventional cardiology · 2020Pooled it
- The Prognostic Impact of New-Onset Persistent Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation: A Meta-analysis.Clinical cardiology · 2016Pooled it
- Prognostic Implications of Right Bundle Branch Block in the General Population: A Systematic Review and Meta-Analysis.Circulation reports · 2026Article
- Association Between Complete Right Bundle Branch Block and Vascular Endothelial Function.JACC. Asia · 2026Article
- Impact of right bundle branch block in anterior ST-segment elevation myocardial infarction in the contemporary primary PCI era.Heart and vessels · 2026Article
- Evaluation of ST-segment and T-wave changes associated with NSTE-ACS in patients with RBBB: a nested case-control study design.Internal and emergency medicine · 2025Article
- Left bundle branch pacing in patients with structural heart disease: personalizing cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Revisiting Abnormalities of Ventricular Depolarization: Redefining Phenotypes and Associated Outcomes Using Tree-Based Dimensionality Reduction.Journal of the American Heart Association · 2025Article
- Prognosis of patients with nonspecific electrocardiogram findings in a Tanzanian emergency department.American heart journal · 2025Article
- Transient right bundle branch block (RBBB) and S1Q3T3 in a transit passenger due to acute pulmonary embolism- a case report.Oxford medical case reports · 2025Article
- Efficient Edge-AI Models for Robust ECG Abnormality Detection on Resource-Constrained Hardware.Journal of cardiovascular translational research · 2024Article
- Ventricular dysfunction consequences of mechanical dyssynchrony in isolated complete right bundle branch block versus left bundle branch block.Quantitative imaging in medicine and surgery · 2024Article
- S4D-ECG: A Shallow State-of-the-Art Model for Cardiac Abnormality Classification.Cardiovascular engineering and technology · 2024Article
- Generalization challenges in electrocardiogram deep learning: insights from dataset characteristics and attention mechanism.Future cardiology · 2024Article
- Left bundle branch pacing with and without anodal capture: impact on ventricular activation pattern and acute haemodynamics.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Bundle branch block in cardiac arrest survivors without ischemic heart disease.International journal of cardiology. Heart & vasculature · 2023Article
- Complete Right Bundle Branch Block as a Predictor of Cardiovascular Events in Type 2 Diabetes.Journal of clinical medicine · 2022Article
- Arrhythmias as Presentation of Genetic Cardiomyopathy.Circulation research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic significance of right bundle branch block (RBBB) is inconsistent across studies. We aimed to assess the association between RBBB (in general population and patients with heart disease) and risk of all-cause mortality, cardiac death, acute myocardial infarction (MI), and heart failure (HF). HYPOTHESIS: RBBB may be associated with increased risk of death.
methodsPubMed, EMBASE, and the Cochrane Library up to February 2015 were searched for prospective cohort studies that reported RBBB at baseline and all-cause mortality, cardiac death, MI, and HF at follow-up. A meta-analysis of published data was undertaken primarily by means of fixed-effects models.
resultsNineteen cohort studies including 201 437 participants were included with a mean follow-up period ranging from 1 to 246 months. For general population with RBBB, the pooled adjusted hazard ratio (HR) for all-cause mortality was 1.17 (95% confidence interval [CI]: 1.03-1.33) compared with no BBB. General population with RBBB had an increased risk of cardiac death (HR: 1.43, 95% CI: 1.17-1.74). For patients with RBBB and acute MI, the pooled risk ratio was 2.31 (95% CI: 2.13-2.49) for in-hospital mortality, 2.85 (95% CI: 2.46-3.30) for 30-day mortality, and 1.96 (95% CI: 1.59-2.42) for longer-term mortality. For acute HF patients, the pooled risk ratio of all-cause mortality was 1.11 (95% CI: 1.06-1.16), and for chronic HF patients it was 1.75 (95% CI: 1.38-2.22).
conclusionsRight bundle branch block is associated with an increased risk of mortality in general population and patients with heart disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.