ArticlePLoS computational biology2015
Genome-Wide Detection and Analysis of Multifunctional Genes.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Systematic detection of predictive gene sets by semantics-based selection.BMC bioinformatics · 2026Article
- High Gene Expression Predicts Extremely Low Segregation of Deleterious Mutations in Large Penguin Populations.Molecular biology and evolution · 2025Article
- A unified analysis of atlas single-cell data.Genome research · 2025Article
- Using clusterProfiler to characterize multiomics data.Nature protocols · 2024Review
- Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekeeping gene regulation.BMC biology · 2024Article
- Article
- Genome-Wide Gene-Set Analysis Approaches in Amyotrophic Lateral Sclerosis.Journal of personalized medicine · 2022Review
- Cooperation loci are more pleiotropic than private loci in the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Seasonal and sex-dependent gene expression in emu (Dromaius novaehollandiae) fat tissues.Scientific reports · 2022Article
- The Effect of Locomotion Mode on Body Shape Evolution in Teleost Fishes.Integrative organismal biology (Oxford, England) · 2021Article
- Multiple Forms of Multifunctional Proteins in Health and Disease.Frontiers in cell and developmental biology · 2020Review
- Gene Set Analysis: Challenges, Opportunities, and Future Research.Frontiers in genetics · 2020Review
- Phylostratigraphic Analysis Shows the Earliest Origination of the Abiotic Stress Associated Genes inGenes · 2019Article
- A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases.Genome medicine · 2019Article
- MoonDB 2.0: an updated database of extreme multifunctional and moonlighting proteins.Nucleic acids research · 2019Article
- Effects of 5-Aminolevulinic Acid on Gene Expression, Immunity, and ATP Levels in Pacific White Shrimp, Litopenaeus vannamei.Marine biotechnology (New York, N.Y.) · 2018Article
- Article
- Mutational Pleiotropy and the Strength of Stabilizing Selection Within and Between Functional Modules of Gene Expression.Genetics · 2018Article
- The Pathway Coexpression Network: Revealing pathway relationships.PLoS computational biology · 2018Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular functioning, thereby leading to a better understanding of the functional landscape of the cell. However, to date, genome-wide analysis of multifunctional genes (and the proteins they encode) has been limited. Here we introduce a computational approach that uses known functional annotations to extract genes playing a role in at least two distinct biological processes. We leverage functional genomics data sets for three organisms--H. sapiens, D. melanogaster, and S. cerevisiae--and show that, as compared to other annotated genes, genes involved in multiple biological processes possess distinct physicochemical properties, are more broadly expressed, tend to be more central in protein interaction networks, tend to be more evolutionarily conserved, and are more likely to be essential. We also find that multifunctional genes are significantly more likely to be involved in human disorders. These same features also hold when multifunctionality is defined with respect to molecular functions instead of biological processes. Our analysis uncovers key features about multifunctional genes, and is a step towards a better genome-wide understanding of gene multifunctionality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.