SynthesisThe Cochrane database of systematic reviews2015
Oral nonsteroidal anti-inflammatory drugs for neuropathic pain.
Synthesis in The Cochrane database of systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07393139 (Early Postoperative Pain and Functional Recovery Following a Limb Amputation), which is not on this map. Cited by 71 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Postoperative Pain and Functional Recovery Following a Limb Amputation: a Retrospective Observational Study.
Who cites it
71 citing papers in PubMed, 13 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Are Cannabis-Based Medicines a Useful Treatment for Neuropathic Pain? A Systematic Review.Biomolecules · 2025Pooled it
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Pregabalin for neuropathic pain in adults.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of empathic and positive communication in healthcare consultations: a systematic review and meta-analysis.Journal of the Royal Society of Medicine · 2018Pooled it
- Cannabis-based medicines for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Systematic review of management of chronic pain after surgery.The British journal of surgery · 2017Pooled it
- A systematic review of the effectiveness of policies restricting access to pregabalin.BMC health services research · 2017Pooled it
- Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Drug therapy for chronic idiopathic axonal polyneuropathy.The Cochrane database of systematic reviews · 2017Pooled it
- Tramadol for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Gabapentin for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Morphine for chronic neuropathic pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Methadone for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Trial
- A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers.Drug design, development and therapy · 2017Trial
- Review
- Clinical practice guidelines for the management of refractory postherpetic neuralgia by the Korean Pain Society.The Korean journal of pain · 2026Review
- Multicomponent Oxicam-Metformin Salts: Toward a Strategy for Enhancing Solubility and Stability.Crystal growth & design · 2026Article
- High-concentration (8%) capsaicin patch for chronic postoperative neuropathic pain: A systematic review of randomised controlled trials.British journal of pain · 2025Article
- UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Complex Regional Pain Syndrome.Brain and behavior · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough often considered to be lacking adequate evidence, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the management of neuropathic pain. Previous surveys found 18% to 47% of affected people reported using NSAIDs specifically for their neuropathic pain, although possibly not in the United Kingdom (UK).
objectivesTo assess the analgesic efficacy of oral NSAIDs for chronic neuropathic pain in adults, when compared to placebo or another active intervention, and the adverse events associated with its use in clinical trials. SEARCH
methodsWe searched CENTRAL, MEDLINE, and EMBASE from inception to 29 May 2015, together with reference lists of retrieved papers and reviews, and an online trials registry. SELECTION CRITERIA: We included randomised, double-blind studies of two weeks duration or longer, comparing any oral NSAID with placebo or another active treatment in chronic neuropathic pain. DATA COLLECTION AND ANALYSIS: Two review authors independently searched for studies, extracted efficacy and adverse event data, and examined issues of study quality. We did not carry out any pooled analysis. MAIN
resultsWe included two studies involving 251 participants with chronic low back pain with a neuropathic component or postherpetic neuralgia; 209 of these participants were involved in a study of an experimental NSAID not used in clinical practice, and of the remaining 42, only 16 had neuropathic pain. This represented only third tier evidence, and was of very low quality. There was no indication of any significant pain reduction with NSAIDs. Adverse event rates were low, with insufficient events for any analysis. AUTHORS'
conclusionsThere is no evidence to support or refute the use of oral NSAIDs to treat neuropathic pain conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.