Evidence map›Paper›PMID 26436531›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2015

Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.

Yingquan Luo, Yu Yang, Hui Zhang, Ting Zhang, Yina Wang, Shengyu Tan, Yan Xu, Dan Li, Ling Ye, Ping Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Molecular heterogeneity in human stroke - What can we learn from the peripheral blood transcriptome?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
  3. Expansion of plasma MicroRNAs over the first month following human stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  4. Smoking affects gene expression in blood of patients with ischemic stroke.Annals of clinical and translational neurology · 2019
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yingquan LuoDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Yu YangDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Hui ZhangDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Ting ZhangDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Yina WangDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Shengyu TanDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Yan XuDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Dan LiDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Ling YeDepartment of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Ping ChenDepartment of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT cell-induced inflammatory response and related cytokine secretion at the injury site may participate in the pathogenesis of cerebral infarction. Recent studies established inducible co-stimulatory molecule (ICOS) as a novel T cell-related factor for its activation and functions. We thus investigate the role of ICOS in cerebral infarction. MATERIAL AND

methodsThe siRNA of ICOS was first used to suppress the gene expression in cultured lymphocytes. An in vivo study was then performed by intravenous application of ICOS siRNA in cerebral infarction rats. Survival rates, neurological scores, serum tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-17 levels were observed.

resultsThe expression of ICOS in cultured lymphocytes was significantly suppressed by siRNA. In the in vivo study, the application of siRNA effectively lowered mortality rates of rats, in addition to the improvement of neurological behaviors and amelioration of cerebral tissue damage. Serum levels of TNF-α, IL-1 and IL-17 were all significantly suppressed after siRNA injection.

conclusionsICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines. These results collectively suggest the potential treatment efficacy of ICOS siRNA against cerebral infarction.

Indexed as

AnimalsCells, CulturedCerebral InfarctionEnzyme-Linked Immunosorbent AssayFemaleGene Expression ProfilingGene Expression RegulationInducible T-Cell Co-Stimulator ProteinInfusions, IntravenousInterleukin-1Interleukin-17LymphocytesMaleRatsRats, Sprague-DawleyRNA, Small InterferingIcos protein, ratIl17a protein, ratInducible T-Cell Co-Stimulator ProteinInterleukin-1Interleukin-17RNA, Small InterferingTumor Necrosis Factor-alpha

Identifiers

PMID26436531
PMCPMC4599179
OpenAlexW1949838662

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.