ArticleNature communications2015
Electrical behaviour of dendritic spines as revealed by voltage imaging.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- Spine-neck electrical bottlenecks tune temporal precision and inhibitory gating in cortical pyramidal neurons: A connectomics-based biophysical study.bioRxiv : the preprint server for biology · 2026Article
- BACE1 Expression Is Required for Proper Synaptic Vesicle Dynamics in the Hippocampus.Journal of neurochemistry · 2025Article
- Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3.Nature communications · 2025Article
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.Brain communications · 2024Article
- Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines.eLife · 2023Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- Excitation-transcription coupling, neuronal gene expression and synaptic plasticity.Nature reviews. Neuroscience · 2023Review
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies.Biosensors · 2023Review
- Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity.Advances in neurobiology · 2023Article
- Comparing synthetic refocusing to deconvolution for the extraction of neuronal calcium transients from light fields.Neurophotonics · 2022Article
- Cell type-specific mechanisms of information transfer in data-driven biophysical models of hippocampal CA3 principal neurons.PLoS computational biology · 2022Article
- Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.Frontiers in molecular neuroscience · 2022Article
- Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy.PLoS biology · 2021Article
- The role of molecular diffusion within dendritic spines in synaptic function.The Journal of general physiology · 2021Review
- QLCA and Entangled States as Single-Neuron Activity Generators.Frontiers in computational neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Thousands of dendritic spines on individual neurons process information and mediate plasticity by generating electrical input signals using a sophisticated assembly of transmitter receptors and voltage-sensitive ion channel molecules. Our understanding, however, of the electrical behaviour of spines is limited because it has not been possible to record input signals from these structures with adequate sensitivity and spatiotemporal resolution. Current interpretation of indirect data and speculations based on theoretical considerations are inconclusive. Here we use an electrochromic voltage-sensitive dye which acts as a transmembrane optical voltmeter with a linear scale to directly monitor electrical signals from individual spines on thin basal dendrites. The results show that synapses on these spines are not electrically isolated by the spine neck to a significant extent. Electrically, they behave as if they are located directly on dendrites.
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Registered trials
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