ArticlePharmacoepidemiology and drug safety2016
Validity and completeness of colorectal cancer diagnoses in a primary care database in the United Kingdom.
Article in Pharmacoepidemiology and drug safety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Identification of validated case definitions for medical conditions used in primary care electronic medical record databases: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2018Pooled it
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- Public health impact of low-dose aspirin on colorectal cancer, cardiovascular disease and safety in the UK - Results from micro-simulation model.International journal of cardiology. Heart & vasculature · 2021Article
- The validity of the claims-based definition of rheumatoid arthritis evaluated in 64 hospitals in Japan.BMC musculoskeletal disorders · 2021Article
- Digoxin use is associated with pancreatic cancer risk but does not affect survival.Cancer causes & control : CCC · 2021Article
- Feasibility study to identify women of childbearing age at risk of pregnancy not using any contraception in The Health Improvement Network (THIN) database.BMC medical informatics and decision making · 2020Article
- Toward the Development of Data Governance Standards for Using Clinical Free-Text Data in Health Research: Position Paper.Journal of medical Internet research · 2020Article
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- Aromatase inhibitors and the risk of colorectal cancer in postmenopausal women with breast cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2018Observational
- New use of low-dose aspirin and risk of colorectal cancer by stage at diagnosis: a nested case-control study in UK general practice.BMC cancer · 2017Article
- Impact of metformin on the progression of MGUS to multiple myeloma.Leukemia & lymphoma · 2017Article
- A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-Onset Diabetes.Gastroenterology · 2017Article
- Validity and completeness of colorectal cancer diagnoses in a primary care database in the United Kingdom.Pharmacoepidemiology and drug safety · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo validate the recorded diagnoses of colorectal cancer (CRC) and identify false negatives in The Health Improvement Network (THIN) primary care database.
methodsWe conducted a validation study of incident CRC cases in THIN among patients aged 40-89 years from 2000-2011. CRC Read code entries (N = 3805) were verified by manual review of patients' electronic medical records (EMRs) including free-text comments. Incident CRC cases in THIN ascertained following manual review were validated against two data sources deemed gold standards: (i) questionnaires sent to primary care practitioners (PCPs; for a random sample of 100 potential CRC cases), and (ii) Hospital Episode Statistics (HES) among linked practices. False negatives in THIN were identified by searching for International Classification of Diseases-10 codes related to CRC in HES.
resultsOf 3805 CRC cases identified in THIN via Read codes, 3033 patients (80.0%) were considered definite cases after manual review of EMRs. The positive predictive value (PPV) of CRC Read codes was 86.0% after removing patients identified from THIN via a Read code for 'fast track referral for suspected CRC'. The response rate from PCPs was 87.0% (n = 87), and the PPV of CRC in THIN was 100% based on PCP questionnaires. Using HES, the PPV for CRC in THIN was 97.9% (556/568), and false negative rate was 6.1% (36/592).
conclusionsCRC diagnostic Read codes in THIN have a high PPV, which is increased further following manual review of free-text comments. The false negative rate of CRC diagnoses in THIN is low.
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