ArticleACS central science2015
Structure-Based Design of Dendritic Peptide Bolaamphiphiles for siRNA Delivery.
Article in ACS central science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Highly Effective Biocides againstACS infectious diseases · 2024Article
- Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective.Accounts of materials research · 2022Article
- Self-assembly of Peptide dendrimers and their bio-applications in theranostics.Materials today. Bio · 2022Article
- Perfluorocarbons in Chemical Biology.Chembiochem : a European journal of chemical biology · 2020Review
- Biomedically Relevant Applications of Bolaamphiphiles and Bolaamphiphile-Containing Materials.Frontiers in chemistry · 2020Review
- Hierarchical Assembly of l-Phenylalanine-Terminated Bolaamphiphile with Porphyrin Show Tunable Nanostructures and Photocatalytic Properties.ACS omega · 2018Article
- Dendritic peptide bolaamphiphiles for siRNA delivery to primary adipocytes.Biomaterials · 2018Article
- Transfection by cationic gemini lipids and surfactants.MedChemComm · 2018Review
- Multicomponent peptide assemblies.Chemical Society reviews · 2018Review
- Functionalized Asymmetric Bola-Type Amphiphiles for Efficient Gene and Drug Delivery.Nanomaterials (Basel, Switzerland) · 2018Article
- Insight into the binding of a non-toxic, self-assembling aromatic tripeptide with ct-DNA: Spectroscopic and viscositic studies.Biochemistry and biophysics reports · 2017Article
- Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery.Biomacromolecules · 2016Article
- Structure-property relationship for in vitro siRNA delivery performance of cationic 2-hydroxypropyl-β-cyclodextrin: PEG-PPG-PEG polyrotaxane vectors.Biomaterials · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Development of safe and effective delivery vectors is a critical challenge for the application of RNA interference (RNAi)-based biotechnologies. In this study we show the rational design of a series of novel dendritic peptide bolaamphiphile vectors that demonstrate high efficiency for the delivery of small interfering RNA (siRNA) while exhibiting low cytotoxicity and hemolytic activity. Systematic investigation into structure-property relationships revealed an important correlation between molecular design, self-assembled nanostructure, and biological activity. The unique bolaamphiphile architecture proved a key factor for improved complex stability and transfection efficiency. The optimal vector contains a fluorocarbon core and exhibited enhanced delivery efficiency to a variety of cell lines and improved serum resistance when compared to hydrocarbon analogues and lipofectamine RNAiMAX. In addition to introducing a promising new vector system for siRNA delivery, the structure-property relationships and "fluorocarbon effect" revealed herein offer critical insight for further development of novel materials for nucleic acid delivery and other biomaterial applications.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.