Evidence map›Paper›PMID 26436137›Full record

ArticleACS central science2015

Partial Saturation of Menaquinone in

Ashutosh Upadhyay, Fabio L Fontes, Mercedes Gonzalez-Juarrero, Michael R McNeil, Debbie C Crans, Mary Jackson, Dean C Crick

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 72 citations in OpenAlex.

  1. Description ofInternational journal of systematic and evolutionary microbiology · 2026
    Article
  2. Asymmetric Reduction of Unactivated Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Review
  4. Article
  5. Structures of Listeria monocytogenes MenD in ThDP-bound and in-crystallo captured intermediate I-bound forms.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
  6. Article
  7. Article
  8. International journal of systematic and evolutionary microbiology · 2025
    Article
  9. Article
  10. Allosteric inhibition ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Genotype-phenotype correlations within theFrontiers in microbiology · 2022
    Article
  16. Presence of Phylloquinone in the Intraerythrocytic Stages ofFrontiers in cellular and infection microbiology · 2022
    Article
  17. Interactions of Truncated Menaquinones in Lipid Monolayers and Bilayers.International journal of molecular sciences · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ashutosh UpadhyayDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Fabio L FontesDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Mercedes Gonzalez-JuarreroDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Michael R McNeilDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Debbie C CransDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Mary JacksonDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Dean C CrickDepartment of Microbiology, Immunology and Pathology, Department of Chemistry, and Cell and Molecular Biology Program, Colorado State University , Fort Collins, Colorado 80523, United States.
Colorado State University · US

Funding

Sterol/Hopanoid Biosynthesis: An Anti-TB Drug TargetR01AI049151 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI CRICK, DEAN C · 2001 to 2019
$4.1M
Menaquinone biosynthesis: a drug target in Gram-positive bacteriaR56AI049151 · NIAID · COLORADO STATE UNIVERSITY · PI CRICK, DEAN C · 2007 to 2007
$320k
NIAID NIH HHS R01 AI049151NIAID NIH HHS R56 AI049151
6 · The paper itself

Abstract

Menaquinone (MK) with partially saturated isoprenyl moieties is found in a wide range of eubacteria and Archaea. In many Gram-positive organisms, including mycobacteria, it is the double bond found in the β-isoprene unit that is reduced. Mass spectral characterization of menaquinone from mycobacterial knockout strains and heterologous expression hosts demonstrates that

Identifiers

PMID26436137
PMCPMC4582327
OpenAlexW2418260175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.