Evidence map›Paper›PMID 26436123›Full record

ArticleVirusdisease2015

Modulation of gene expression in CD4+ T lymphocytes following in vitro HIV infection: a comparison between human and chimpanzee.

Bénédicte Puissant-Lubrano, Pol-André Apoil, Arnaud Gleizes, Lionel Forestier, Raymond Julien, Peter Winterton, Christophe Pasquier, Jacques Izopet, Antoine Blancher

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virusdisease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bénédicte Puissant-LubranoLaboratoire d'Immunogénétique Moléculaire (EA3034), Faculté de médecine Toulouse- Rangueil, Université Paul Sabatier, Bâtiment A2, 133 Route de Narbonne, 31062 Toulouse Cedex 04, France.
Pol-André Apoil *Laboratoire d'Immunogénétique Moléculaire (EA3034), Faculté de médecine Toulouse- Rangueil, Université Paul Sabatier, Bâtiment A2, 133 Route de Narbonne, 31062 Toulouse Cedex 04, France.
Arnaud Gleizes *Laboratoire d'Immunogénétique Moléculaire (EA3034), Faculté de médecine Toulouse- Rangueil, Université Paul Sabatier, Bâtiment A2, 133 Route de Narbonne, 31062 Toulouse Cedex 04, France.
Lionel ForestierInstitut des Sciences de la Vie et de la Santé, Université de Limoges (EA3 176), Limoges, France.
Raymond JulienInstitut des Sciences de la Vie et de la Santé, Université de Limoges (EA3 176), Limoges, France.
Peter WintertonUniversité de Toulouse-Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France.
Christophe PasquierLaboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, TSA 40031, 31059 Toulouse Cedex 9, France.
Jacques IzopetLaboratoire de Virologie, CHU de Toulouse, Hôpital Purpan, TSA 40031, 31059 Toulouse Cedex 9, France.
Antoine BlancherLaboratoire d'Immunogénétique Moléculaire (EA3034), Faculté de médecine Toulouse- Rangueil, Université Paul Sabatier, Bâtiment A2, 133 Route de Narbonne, 31062 Toulouse Cedex 04, France.
Centre Hospitalier Universitaire de Toulouse · FRInstitut de Virologie · FRUniversité de Limoges · FRUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimpanzees are susceptible to experimental infection by human deficiency virus (HIV)-1, but unlike humans, they exceptionally develop an immunodeficiency syndrome after HIV-1 inoculation. To explore the difference between human and chimpanzee, we analyzed the expression of 1547 genes of various functions in human or chimpanzee CD4+ lymphoblasts inoculated in vitro with HIV-1. We observed that, 1 day after HIV inoculation, fifty-eight genes were up-regulated in lymphoblasts of the three humans while their expression remained unchanged in lymphoblasts of the three chimpanzees. One gene is involved in adhesion of HIV (catenin-alpha), three in the immune response (semaphorin 4D, placental growth factor, IL-6), three in apoptosis (deleted in colorectal carcinoma, caspase 9 and FOXO1A). No difference between species was revealed for the expression of 373 genes related to glycosylation pathways. The in vitro human/chimpanzee comparison reveals new candidate genes up-regulated after inoculation with HIV-1 only in human lymphoblasts and which could be related to the higher sensitivity of human to HIV-induced AIDS.

Indexed as

ArrayCD4+ T lymphocytesHumanImmune responseNon-human primatesqPCR

Identifiers

PMID26436123
PMCPMC4585051
OpenAlexW954071604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.