Evidence map›Paper›PMID 26436069›Full record

ArticleJournal of diabetes and metabolic disorders2015

Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes.

Arpana Gaddam, Chandrakala Galla, Sreenivas Thummisetti, Ravi Kumar Marikanty, Uma D Palanisamy, Paturi V Rao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 5 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Interventions for Reversing Prediabetes: A Systematic Review and Meta-Analysis.American journal of preventive medicine · 2022 · on this map
    Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Review
  11. Antidiabetic potential of fenugreek (Food science & nutrition · 2024
    Review
  12. The Role of Fenugreek in the Management of Type 2 Diabetes.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
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  17. Article
  18. Role of Fenugreek, Cinnamon,Pharmaceuticals (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Arpana GaddamDepartment of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.
Chandrakala GallaDepartment of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.
Sreenivas ThummisettiDepartment of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.
Ravi Kumar MarikantyDepartment of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.
Uma D PalanisamySchool of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia.
Paturi V RaoDepartment of Endocrinology and Metabolism, Nizam's Institute of Medical Sciences University, Punjagutta, Hyderabad, 500082 India.
Nizam's Institute of Medical Sciences · INMonash University Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is hypothesized that dietary supplementation with Fenugreek modulates glucose homeostasis and potentially prevents diabetes mellitus in people with prediabetes. The objective of present study is to determine whether Fenugreek can prevent the outcome of T2DM in non diabetic people with prediabetes.

methodsA 3-year randomized, controlled, parallel study for efficacy of Fenugreek (n = 66) and matched controls (n = 74) was conducted in men and women aged 30-70 years with criteria of prediabetes. Fenugreek powder, 5 g twice a day before meals, was given to study subjects and progression of type 2 diabetes mellitus (T2DM) was monitored at baseline and every 3 months for the 3-year study.

resultsBy the end of intervention period, cumulative incidence rate of diabetes reduced significantly in Fenugreek group when compared to controls. The Fenugreek group also saw a significant reduction in fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and low density lipoprotein cholesterol (LDLc) whereas serum insulin increased significantly. It was observed that controls had 4.2 times higher chance of developing diabetes compared to subjects in the Fenugreek group. The outcome of diabetes in Fenugreek group was positively associated with serum insulin and negatively associated with insulin resistance (HOMA IR).

conclusionsDietary supplementation of 10 g Fenugreek/day in prediabetes subjects was associated with lower conversion to diabetes with no adverse effects and beneficial possibly due to its decreased insulin resistance.

Indexed as

FenugreekImpaired fasting glucoseImpaired glucose tolerancePrediabetes

Identifiers

PMID26436069
PMCPMC4591578
OpenAlexW2117706489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.