Evidence map›Paper›PMID 26435945›Full record

ArticleJournal of clinical and diagnostic research : JCDR2015

Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus from Sub Himalayan Region of India.

Kiran K Mokta, Santwana Verma, Divya Chauhan, Sunite A Ganju, Digvijay Singh, Anil Kanga, Anita Kumari, Vinod Mehta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Prevalence of Methicillin-resistantOman medical journal · 2022
    Review
  4. Inducible Clindamycin-ResistantInternational journal of microbiology · 2022
    Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kiran K MoktaAssistant Professor, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Santwana VermaAssociate Professor, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Divya ChauhanSenior Resident, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Sunite A GanjuAssistant Professor, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Digvijay SinghProfessor, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Anil KangaProfessor and Head, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Anita KumariJunior Resident, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Vinod MehtaJunior Resident, Department of Microbiology, Indira Gandhi Medical College , Shimla, India .
Indira Gandhi Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClindamycin is an alternative antibiotic in the treatment of Staphylococcus aureus (S.aureus) infections, both in infections by methicillin susceptible and resistant (MSSA and MRSA) strains. The major problem of use of clindamycin for staphylococcal infections is the presence of inducible clindamycin resistance that can lead to treatment failure in such infections.

aimTo determine inducible and constitutive clindamycin resistance among clinical isolates of S. aureus in a tertiary care centre of sub Himalayan region of India. MATERIALS AND

methodsA total of 350 isolates of S. aureus from various clinical samples were subjected to routine antibiotic sensitivity testing by Kirby Bauer disc diffusion method. Methicillin resistance was detected by cefoxitin (30μg) disc. All isolates were subjected to inducible clindamycin resistance was by Clinical Laboratory Standards Institute (CLSI) recommended D test.

resultsAmong 350 S.aureus isolates, 82 (23.42%) were MRSA and 268 (76.57%) were MSSA. Erythromycin resistance was detected in 137 (39.14%) isolates. Erythromycin resistance in MRSA and MSSA was 71.6% and 29.36% respectively. Overall clindamycin resistance was seen in 108 (30.85%) isolates. Constitutive MSLB phenotype predominated (29.62% MRSA; 13.38% MSSA) followed by iMLSB (28.39% MRSA; 9.29% MSSA) and MS phenotypes (13.58% MRSA; 6.69%MSSA). Both inducible and constitutive clindamycin resistance was significantly higher (p=0.00001, 0.0008 respectively) in methicillin resistant strains than in methicillin susceptible strains.

conclusionThe present study gives a magnitude of clindamycin resistance among clinical isolates of S. aureus from this region of the country. Our study recommends routine testing of inducible clindamycin resistance at individual settings to guide optimum therapy and to avoid treatment failure.

Indexed as

Constitutive clindamycin resistanceD testInducible clindamycin resistanceStaphylococcus aureus

Identifiers

PMID26435945
PMCPMC4576536
OpenAlexW2405226576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.