Evidence map›Paper›PMID 26435940›Full record

ArticleJournal of clinical and diagnostic research : JCDR2015

Analysis of Antibiotic Resistance Genes and its Associated SCCmec Types among Nasal Carriage of Methicillin Resistant Coagulase Negative Staphylococci from Community Settings, Chennai, Southern India.

Saravanan Murugesan, Nagaraj Perumal, Surya Prakash Mahalingam, Selva Kumar Dilliappan, Padma Krishnan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Global prevalence of macrolide-resistantFrontiers in microbiology · 2025
    Pooled it
  2. Molecular Variation of Methicillin-resistantRecent patents on biotechnology · 2026
    Article
  3. Molecular Characterization of Cefoxitin-Resistant Coagulase-Negative Staphylococci From Frequently Touched Surfaces of Hospital and Urban-Built Environments of Central India.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  4. Article
  5. Article
  6. Spectrum of Virulence Factors in Clinical Isolates ofJournal of laboratory physicians · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A Review of Staphylococcal Cassette ChromosomeThe Malaysian journal of medical sciences : MJMS · 2017
    Review
  12. Detection of Integrons and Staphylococcal Cassette ChromosomeOsong public health and research perspectives · 2017
    Article
  13. Assessment ofPharmacognosy magazine · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saravanan MurugesanResearch Scholar, Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai, India .
Nagaraj PerumalResearch Scholar, Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai, India .
Surya Prakash MahalingamProject Trainee, Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai, India .
Selva Kumar DilliappanProject Trainee, Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai, India .
Padma KrishnanAssistant Professor, Department of Microbiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai, India .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study was designed to find the distribution of SCCmec types and the various antibiotic resistance genes amongst MR-CoNS isolates from asymptomatic individuals. MATERIALS AND

methodsA total of 145 nasal swabs were collected from asymptomatic healthy individuals from community settings. Identification and speciation of CoNS were done by standard biochemical methods. Screening of methicillin resistance (mecA gene) and detection of various antibiotic resistant genes were done using multiplex PCR method. SCCmec types (I - V) were determined using multiplex PCR.

results50 (44.6%) isolates were found to be methicillin resistant both by cefoxitin method and multiplex PCR. S. epidermidis (40%) was the predominant species followed by S. haemolyticus (28%), S. hominis (20%) and S. warneri (12%). Highest resistance was shown for cotrimoxazole (26%), followed by ciprofloxacin (24%), tetracycline (20%), erythromycin (18%), fusidic acid (10%) and mupirocin (6%). Among SCCmec types, 44 isolates showed single type, including type I (30%), type IV (24%), type II (18%), type V (14%) and type III (2%). 6 isolates showed two types, III+IV (n= 2), II+V (n=2), IV+V (n=1) and type I+V (n=1).

conclusionIn conclusion, to the best of our knowledge, this is the first study in India to study the distribution of antibiotic resistant genes and SCCmec types among MR-CoNS from community settings. This study highlights high prevalence of MR-CoNS in community and its role in harbouring genetically diverse SCCmec elements as antibiotic resistance determinant.

Indexed as

Antibiotic resistanceAsymptomatic healthy individualsMR-CoNSNasal carriageSCCmec

Identifiers

PMID26435940
PMCPMC4576531

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