ArticleQuantitative imaging in medicine and surgery2015
The effect of changes to MOLLI scheme on T1 mapping and extra cellular volume calculation in healthy volunteers with 3 tesla cardiovascular magnetic resonance imaging.
Article in Quantitative imaging in medicine and surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease.The international journal of cardiovascular imaging · 2020Pooled it
- Left ventricular fibrosis and hypertrophy are associated with mortality in heart failure with preserved ejection fraction.Scientific reports · 2021Trial
- Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map.Scientific reports · 2026Article
- Free-Breathing Ungated Radial Simultaneous Multi-Slice Cardiac T1 Mapping.Journal of magnetic resonance imaging : JMRI · 2025Article
- Advancing Myocardial T1 Mapping: A Comparative Study of the Frequency-Independent MFA Sequence and Standard MOLLI.NMR in biomedicine · 2025Article
- Native myocardial TRadiological physics and technology · 2024Article
- Reference ranges of myocardial T1 and T2 mapping in healthy Chinese adults: a multicenter 3T cardiovascular magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Accelerated cardiac T1 mapping with recurrent networks and cyclic, model-based loss.Medical physics · 2022Article
- The role of native T1 values on the evaluation of cardiac manifestation in Japanese Fabry disease patients.Molecular genetics and metabolism reports · 2022Article
- Reference Values of Native T1 at 3T Cardiac Magnetic Resonance-Standardization Considerations between Different Vendors.Diagnostics (Basel, Switzerland) · 2021Article
- T1 and T2∗ relaxation time in the parcellated myocardium of healthy Taiwanese participants: A single center study.Biomedical journal · 2021Article
- Native T1 mapping and extracellular volume fraction for differentiation of myocardial diseases from normal CMR controls in routine clinical practice.BMC cardiovascular disorders · 2021Article
- Magnetic resonance fingerprinting of the pancreas at 1.5 T and 3.0 T.Scientific reports · 2020Article
- Normative Data for Myocardial Native T1 and Extracellular Volume Fraction in Children.Radiology. Cardiothoracic imaging · 2020Article
- Cardiovascular MRI evidence of reduced systolic function and reduced LV mass in rheumatoid arthritis: impact of disease phenotype.The international journal of cardiovascular imaging · 2020Article
- Comparison of Intravoxel Incoherent Motion Diffusion-Weighted Magnetic Resonance (MR) Imaging to T1 Mapping in Characterization of Hepatic Alveolar Echinococcosis.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- 3D myocardial TJournal of magnetic resonance imaging : JMRI · 2017Article
- Effect of cellular and extracellular pathology assessed by T1 mapping on regional contractile function in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
- Native myocardial longitudinal (T1 ) relaxation time: Regional, age, and sex associations in the healthy adult heart.Journal of magnetic resonance imaging : JMRI · 2016Article
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11 authors.
Funding
Abstract
backgroundDiffuse myocardial fibrosis may be quantified with magnetic resonance (MR) by calculating extracellular volume (ECV) fraction from native and post-contrast T1 values. The ideal modified look-locker inversion recovery (MOLLI) sequence for deriving T1 values has not been determined. This study aims to establish if systematic differences exist between suggested MOLLI schemes.
methodsTwelve phantom gels were studied with inversion recovery spin echo MR at 3.0 tesla to determine reference T1. Gels were then scanned with six MOLLI sequences (3s)3b(3s)5b; 4b(3s)3b(3s)2b; 5b(3s)3b with flip angles of both 35° and 50° at a range of heart rates (HRs). In 10 healthy volunteers MOLLI studies were performed on two separate occasions. Mid ventricular native and post contrast T1 was measured and ECV (%) calculated.
resultsIn phantoms, the co-efficient of variability at simulated HR [40-100] with a flip angle of 35° ranged from 6.77 to 9.55, and at 50° from 7.71 to 11.10. T1 was under-estimated by all MOLLI acquisitions. Error was greatest with longer T1, and increased as HR increased. The 10 volunteers had normal MR studies. Native T1 time was similar for all acquisitions but highest with the 5b(3s)3b 35° scheme (1,189.1±33.46 ms). Interstudy reproducibility was similar for all MOLLIs.
conclusionsThe 5b(3s)3b MOLLI scheme agreed best with reference T1, without statistical difference between the six schemes. The shorter breath-hold time of 5b(3s)3b scheme may be preferable in clinical studies and warrants further investigation.
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