Evidence map›Paper›PMID 26435825›Full record

ArticleElectronic physician2015

Probiotic for irritable bowel syndrome in pediatric patients: a randomized controlled clinical trial.

Hamidreza Kianifar, Seyed Ali Jafari, Mohammadali Kiani, Hamid Ahanchian, Seyed Vahid Ghasemi, Zubin Grover, Leili Zarif Mahmoodi, Rita Bagherian, Maryam Khalesi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electronic physician, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 8 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 8 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Dietary interventions for recurrent abdominal pain in childhood.The Cochrane database of systematic reviews · 2017
    Pooled it
  9. Trial
  10. Review
  11. Review
  12. Review
  13. Article
  14. Impact ofNutrients · 2024
    Review
  15. Review
  16. Probiotics in Functional Gastrointestinal Disorders.Advances in experimental medicine and biology · 2024
    Review
  17. Article
  18. Article
  19. An Update on the Assessment and Management of Pediatric Abdominal Pain.Pediatric health, medicine and therapeutics · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hamidreza KianifarMD, Associate Professor, Department of Pediatric Gastroenterology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Ali JafariMD, Associate Professor, Department of Pediatric Gastroenterology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadali KianiMD, Associate Professor, Department of Pediatric Gastroenterology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamid AhanchianMD, Associate Professor, Department of Pediatric Immunology and Allergy, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Vahid GhasemiMD, Pediatrician, Department of Pediatrics, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zubin GroverMD, Associate Professor, Queensland Children's Medical Research Institute, Royal Children's Hospital, Brisbane, Queensland, Australia.
Leili Zarif MahmoodiPh.D., Faculty Member, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Rita BagherianMD, Faculty Member, Department of Pediatric Gastroenterology, Tehran University of Medical Sciences, Tehran, Iran.
Maryam KhalesiMD, Assistant Professor, Department of Pediatrics, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IRRoyal Children's Hospital · AUTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIrritable bowel syndrome (IBS) is a common gastrointestinal disorder in children. Recently, probiotics have been suggested as a treatment option for gastrointestinal disorders. The most effective species and the most appropriate doses are still unknown.

objectiveThe aim of this study was to assess the effects of Lactobacillus GG (LGG) for treating IBS in pediatric patients.

methodsIn a controlled, double blind, randomized trial, patients with IBS diagnosed by Rome III criteria from August 2012 to September 2012 at Dr. Sheikh Hospital, Mashhad University of Medical Sciences, Iran, were assigned to one of two groups, i.e., intervention and control groups. For four weeks, the intervention group received a probiotic in capsule form that contained LGG at a concentration of 1×10(10) cfu/ml bacteria. For the same period, the control group received a placebo capsule that had the same shape and color but only contained inulin, which also was present in the LGG capsules. The primary outcome was any change in the severity of the patients' pain, and we used a five-point Likert scale to evaluate the severity of their pain. Secondary outcomes were ghanges of the functional scale, stool patterns, and associated problems.

resultsFifty-two patients participated in the study, and 26 patients were assigned randomly to each of the two groups. The severity of the patients' pain decreased significantly in the intervention group after one, two, three, and four weeks of treatment, as indicated by P-values of 0.01, 0.00, 0.00, and 0.00, respectively. Also, there was significant improvement in the functional scale after two weeks of treatment (P-value ≤ 0.00).

conclusionLactobacillus GG at a concentration of 1×10(10) cfu/ml for a period of four weeks can lessen the severity of the patients' pain and improve the functional scale in patients with irritable bowel syndrome. Probiotics can have therapeutic effects for IBS patients.

Indexed as

childrenirritable bowel syndromeprobiotics

Identifiers

PMID26435825
PMCPMC4590561
OpenAlexW2407012166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.