Evidence map›Paper›PMID 26435649›Full record

ArticleHippokratia

In vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in Mycoplasma pneumoniae.

G Ou, Y Liu, Y Tang, X You, Y Zeng, J Xiao, L Chen, M Yu, M Wang, C Zhu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Hippokratia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Genomic epidemiological analysis reveals new insights into the resurgence ofFrontiers in cellular and infection microbiology · 2025
    Article
  2. Article
  3. Novel mechanisms of macrolide resistance revealed byFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

G OuInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
Y LiuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Y TangShaoyang Medical College, Shaoyang City, Hunan Province, P.R. China.
X YouInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
Y ZengInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
J XiaoInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
L ChenInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
M YuInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
M WangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, P.R. China.
C ZhuInstitution of Pathogenic Biology, Medical College, University of South China, Hunan Provincial Key, Laboratory for Special Pathogens Prevention and Control, Hengyang City, Hunan Province, P.R. China.
University of South China · CNHuashan Hospital · CNShaoyang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aims to investigate the inducing effect of subminimum inhibitory concentrations of macrolide antibiotics on Mycoplasma pneumoniae (M. pneumoniae) resistance to drugs. MATERIALS AND

methodsOne M. pneumoniae reference strain M129 (ATCC 29342) and 104 clinical isolates were incubated at 37C for 6-8 days. Genomic DNA of M. pneumoniae was extracted using TIANamp Bacteria DNA kit and amplified by polymerase chain reaction (PCR).

resultsTen sensitive isolates obtained from 104 M. pneumoniae clinical isolates were induced by subminimum inhibitory concentrations of macrolide antibiotics. Among them, three were found to possess mutations in L4 and L22 ribosomal proteins. Two cases carried simultaneously the C162A and A430G mutations of L4 and the T279C mutation of L22. In addition, one case had only the A209T mutation of L4.

conclusionsRepeated in vitro exposure to subminimum inhibitory concentrations of macrolide antibiotics could induce selective mutations in ribosomal genes of M. pneumoniae clinical isolates that cause resistance to macrolide antibiotics. Hippokratia 2015, 19 (1): 57-62.

Indexed as

Macrolide resistanceMycoplasma pneumoniaesubminimum inhibitory concentration

Identifiers

PMID26435649
PMCPMC4574589
OpenAlexW2397574074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.