Evidence map›Paper›PMID 26435566›Full record

ArticleDisease markers2015

Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk.

Adina Stoian, Claudia Bănescu, Rodica Ioana Bălaşa, Anca Moţăţăianu, Mircea Stoian, Valeriu G Moldovan, Septimiu Voidăzan, Minodora Dobreanu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Article
  6. Genetic Variants Influence the Development of Diabetic Neuropathy.International journal of molecular sciences · 2024
    Review
  7. Review
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  9. Review
  10. Glutathione S-Transferase P1 Genetic Variant's Influence on the HbA1c Level in Type Two Diabetic Patients.International journal of environmental research and public health · 2023
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adina StoianDepartment of Pathophysiology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Claudia BănescuDepartment of Medical Genetics, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Rodica Ioana BălaşaDepartment of Neurology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Anca MoţăţăianuDepartment of Neurology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Mircea StoianIntensive Care Unit, Mureș County Hospital, Bernády György 6, 540000 Tîrgu Mureş, Romania.
Valeriu G MoldovanDepartment of Medical Genetics, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Septimiu VoidăzanDepartment of Epidemiology, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Minodora DobreanuDepartment of Laboratory Medicine, University of Medicine and Pharmacy, Gheorghe Marinescu 38, 540139 Tîrgu Mureş, Romania.
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș · ROSpitalul Clinic Judetean Mures · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsDiabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN).

methodsSamples were collected from 84 patients with T2DM (42 patients with DN and 42 patients without DN) and 98 healthy controls and genotyped by using polymerase chain reaction and restriction fragment length polymorphism method.

resultsGSTP1 Ile105Val polymorphism was associated with the risk of developing T2DM (p = 0.05) but not with the risk of developing DN in diabetic cases. GSTM1 and GSTT1 gene polymorphisms were associated with neither the risk of developing T2DM nor the risk of DN occurrence in diabetic patients. No association was observed between the patients with T2DM and DSPN (diabetic sensorimotor peripheral neuropathy) and T2DM without DSPN regarding investigated polymorphism.

conclusionOur data suggest that GSTP1 gene polymorphisms may contribute to the development of T2DM in Romanian population. GSTM1, GSTT1, and GSTP1 gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients.

Indexed as

Polymorphism, Single NucleotideAgedCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleGlutathione S-Transferase piGlutathione TransferaseHumansMaleMiddle AgedGlutathione S-Transferase piglutathione S-transferase T1Glutathione TransferaseGSTP1 protein, human

Identifiers

PMID26435566
PMCPMC4578743
OpenAlexW1704792035

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.