Evidence map›Paper›PMID 26435524›Full record

ReviewAddiction biology2016

Neural substrates of cue reactivity: association with treatment outcomes and relapse.

Kelly E Courtney, Joseph P Schacht, Kent Hutchison, Daniel J O Roche, Lara A Ray

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Addiction biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 8 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 8 syntheses or guidelines pooled it, 243 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kelly E CourtneyDepartment of Psychology, University of California, Los Angeles, CA, USA.
Joseph P SchachtDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Kent HutchisonDepartment of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
Daniel J O RocheDepartment of Psychology, University of California, Los Angeles, CA, USA.
Lara A RayDepartment of Psychology, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USMedical University of South Carolina · USNeurobehavioral Systems · USUniversity of Colorado Boulder · US

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Patrick J. Mulholland · 1996 to 2026
$46.8M
The Effects of Naltrexone on Neural Responses to Methamphetamine CuesF31DA035604 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COURTNEY, KELLY ELIZABETH · 2013 to 2014
$66k
NIAAA NIH HHS P50 AA010761NIDA NIH HHS F31 DA035604
6 · The paper itself

Abstract

Given the strong evidence for neurological alterations at the basis of drug dependence, functional magnetic resonance imaging (fMRI) represents an important tool in the clinical neuroscience of addiction. fMRI cue-reactivity paradigms represent an ideal platform to probe the involvement of neurobiological pathways subserving the reward/motivation system in addiction and potentially offer a translational mechanism by which interventions and behavioral predictions can be tested. Thus, this review summarizes the research that has applied fMRI cue-reactivity paradigms to the study of adult substance use disorder treatment responses. Studies utilizing fMRI cue-reactivity paradigms for the prediction of relapse and as a means to investigate psychosocial and pharmacological treatment effects on cue-elicited brain activation are presented within four primary categories of substances: alcohol, nicotine, cocaine and opioids. Lastly, suggestions for how to leverage fMRI technology to advance addiction science and treatment development are provided.

Indexed as

CuesAlcoholismBrainCocaine-Related DisordersFunctional NeuroimagingHumansMagnetic Resonance ImagingOpioid-Related DisordersPrognosisRecurrenceTobacco Use DisorderTranslational Research, BiomedicalTreatment OutcomeAddictioncue reactivityfMRImedication developmentsubstance use disordertreatment

Identifiers

PMID26435524
PMCPMC4986996
OpenAlexW1855337730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.