ArticleScientific reports2015
Endometrial gene expression profile of pregnant sows with extreme phenotypes for reproductive efficiency.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Identification of trait-associated microRNA modules in liver transcriptome of pig fed with PUFAs-enriched supplementary diet.Journal of applied genetics · 2025Article
- Insights into the single-cell transcriptome characteristics of porcine endometrium with embryo loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Transcriptomic Data Analyses Reveal That Sow Fertility-Related lincRNAFrontiers in cell and developmental biology · 2021Article
- Insights Into Extracellular Vesicle/Exosome and miRNA Mediated Bi-Directional Communication During Porcine Pregnancy.Frontiers in veterinary science · 2021Review
- Article
- Integrated Analysis of miRNA-mRNA Network Reveals Different Regulatory Patterns in the Endometrium of Meishan and Duroc Sows during Mid-Late Gestation.Animals : an open access journal from MDPI · 2020Article
- EPS-LASSO: test for high-dimensional regression under extreme phenotype sampling of continuous traits.Bioinformatics (Oxford, England) · 2018Article
- Insertion/Deletion Within the KDM6A Gene Is Significantly Associated With Litter Size in Goat.Frontiers in genetics · 2018Article
- Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA-mRNA interactome.Biology of reproduction · 2017Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolificacy can directly impact porcine profitability, but large genetic variation and low heritability have been found regarding litter size among porcine breeds. To identify key differences in gene expression associated to swine reproductive efficiency, we performed a transcriptome analysis of sows' endometrium from an Iberian x Meishan F2 population at day 30-32 of gestation, classified according to their estimated breeding value (EBV) as high (H, EBV > 0) and low (L, EBV < 0) prolificacy phenotypes. For each sample, mRNA and small RNA libraries were RNA-sequenced, identifying 141 genes and 10 miRNAs differentially expressed between H and L groups. We selected four miRNAs based on their role in reproduction, and five genes displaying the highest differences and a positive mapping into known reproductive QTLs for RT-qPCR validation on the whole extreme population. Significant differences were validated for genes: PTGS2 (p = 0.03; H/L ratio = 3.50), PTHLH (p = 0.03; H/L ratio = 3.69), MMP8 (p = 0.01; H/L ratio =4.41) and SCNN1G (p = 0.04; H/L ratio = 3.42). Although selected miRNAs showed similar expression levels between H and L groups, significant correlation was found between the expression level of ssc-miR-133a (p < 0.01) and ssc-miR-92a (p < 0.01) and validated genes. These results provide a better understanding of the genetic architecture of prolificacy-related traits and embryo implantation failure in pigs.
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