ArticleScientific reports2015
Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Global trends and molecular epidemiology of Azithromycin-resistantOne health (Amsterdam, Netherlands) · 2026Article
- Prevalence and characterization of ciprofloxacin-resistantThe veterinary quarterly · 2025Article
- Unraveling the treasure trove of phytochemicals in mitigating the Salmonella enterica infection.Folia microbiologica · 2025Review
- Clonal Spread and Genetic Mechanisms Underpinning Ciprofloxacin Resistance inFoods (Basel, Switzerland) · 2025Article
- Coexistence of plasmid-mediated quinolone resistance (PMQR) and extended-spectrum beta-lactamase (ESBL) genes among clinical Pseudomonas aeruginosa isolates in Egypt.BMC microbiology · 2024Article
- PredictingMicroorganisms · 2024Article
- Prevalence and molecular characterization of cefotaxime-resistantMicrobiology spectrum · 2023Article
- Identification and Genetic Characterization of Conjugative Plasmids Encoding Coresistance to Ciprofloxacin and Cephalosporin in FoodborneMicrobiology spectrum · 2023Article
- Serotypes, Antimicrobial Resistance Profiles, and Virulence Factors ofFoods (Basel, Switzerland) · 2023Article
- Comparative Studies of Antimicrobial Resistance inFoods (Basel, Switzerland) · 2023Article
- Broad lytic spectrum of novelVeterinary world · 2022Article
- A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect againstAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance and Virulence of Non-TyphoidalFoods (Basel, Switzerland) · 2022Article
- Genomic Characterization ofFrontiers in microbiology · 2022Article
- Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases ofAntibiotics (Basel, Switzerland) · 2021Review
- Antimicrobial Susceptibility and Frequency ofAntibiotics (Basel, Switzerland) · 2021Article
- The Occurrence of Antimicrobial-ResistantAnimals : an open access journal from MDPI · 2021Article
- Contribution of Different Mechanisms to Ciprofloxacin Resistance inFrontiers in microbiology · 2021Article
- Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China.BMC microbiology · 2020Article
- Identifying emerging trends in antimicrobial resistance using Salmonella surveillance data in poultry in Spain.Transboundary and emerging diseases · 2020Article
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4 authors.
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Abstract
Fluoroquinolone resistance in Salmonella has become increasingly prevalent in recent years. To probe the molecular basis of this phenomenon, the genetic and phenotypic features of fluoroquinolone resistant Salmonella strains isolated from food samples were characterized. Among the 82 Salmonella strains tested, resistance rate of the three front line antibiotics of ceftriaxone, ciprofloxacin and azithromycin was 10%, 39% and 25% respectively, which is significantly higher than that reported in other countries. Ciprofloxacin resistant strains typically exhibited cross-resistance to multiple antibiotics including ceftriaxone, primarily due to the presence of multiple PMQR genes and the blaCTX-M-65, blaCTX-M-55 blaCMY-2 and blaCMY-72 elements. The prevalence rate of the oqxAB and aac(6')-Ib-cr genes were 91% and 75% respectively, followed by qnrS (66%), qnrB (16%) and qnrD (3%). The most common PMQR combination observable was aac(6')-Ib-cr-oqxAB-qnrS2, which accounted for 50% of the ciprofloxacin resistant strains. Interestingly, such isolates contained either no target mutations or only a single gyrA mutation. Conjugation and hybridization experiments suggested that most PMQR genes were located either in the chromosome or a non-transferrable plasmid. To summarize, findings in this work suggested that PMQRs greatly facilitate development of fluoroquinolone resistance in Salmonella by abolishing the requirement of target gene mutations.
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