Evidence map›Paper›PMID 26435268›Full record

ArticleChild development

Sleep Disturbance and Expressive Language Development in Preschool-Age Children With Down Syndrome.

Jamie O Edgin, Ursula Tooley, Bianca Demara, Casandra Nyhuis, Payal Anand, Goffredina Spanò

2 registry-linked trialsAbstract read
In one paragraph

Article in Child development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03922165 completednot on this map

Healthy Sleep for Children With Down Syndrome

TypeobservationalSponsorBrigham and Women's HospitalRan2019 to 2021Enrolled26ConditionsDown Syndrome, Sleep Disordered BreathingArmsAdenotonsillectomy
NCT06043440 phase2recruitingnot on this map

Randomized Control Trial of Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea

TypeinterventionalSponsorBrigham and Women's HospitalRan2023 to 2027Enrolled230ConditionsDown Syndrome, Obstructive Sleep ApneaArmsOxygen
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. The Canadian 24-Hour Movement Guidelines for Preschoolers With Disabilities: Occupational Therapists' Perspectives.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2026
    Article
  3. Developmental Profile and Variability in Preschool-Age Children With Down Syndrome.Journal of intellectual disability research : JIDR · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Quality of Life and Mental Health in Caregivers of Children With Down Syndrome and Sleep Problems.Journal of applied research in intellectual disabilities : JARID · 2025
    Article
  8. Article
  9. Neuronal oscillations in cognition: Down syndrome as a model of mouse to human translation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jamie O EdginUniversity of Arizona and Sonoran University Center for Excellence in Developmental Disabilities.
Ursula TooleyUniversity of Arizona and Sonoran University Center for Excellence in Developmental Disabilities.
Bianca DemaraUniversity of Arizona and Sonoran University Center for Excellence in Developmental Disabilities.
Casandra NyhuisUniversity of Arizona and Sonoran University Center for Excellence in Developmental Disabilities.
Payal AnandUniversity of Arizona and Sonoran University Center for Excellence in Developmental Disabilities.
Goffredina SpanòUniversity of Arizona and Sonoran University Center for Excellence in Developmental Disabilities.
University of Arizona · US

Funding

MARC/Biomedical Research and Training Program at the University of ArizonaT34GM008718 · NIGMS · UNIVERSITY OF ARIZONA · PI MIRANDA, KATRINA M. · 1999 to 2021
$8.6M
Expressive Language Sampling as an Outcome MeasureR01HD074346 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2017
$3.9M
Howard Hughes Medical Institute 52006942NICHD NIH HHS R01 HD074346NICHD NIH HHS R01HD07434601A1NIGMS NIH HHS 5-T34-GM-008718NIGMS NIH HHS T34 GM008718
6 · The paper itself

Abstract

Recent evidence has suggested that sleep may facilitate language learning. This study examined variation in language ability in 29 toddlers with Down syndrome (DS) in relation to levels of sleep disruption. Toddlers with DS and poor sleep (66%, n = 19) showed greater deficits on parent-reported and objective measures of language, including vocabulary and syntax. Correlations between sleep and language were found in groups with equivalent medical and social backgrounds and after control for relevant behavioral comorbidities, including autism symptoms. These results emphasize the important role of quality sleep in all children's expressive language development, and may help increase our understanding of the etiology of language deficits in developmental disorders, potentially leading to new treatment approaches.

Indexed as

Language DevelopmentChild, PreschoolDown SyndromeFemaleHumansMaleSleep Wake DisordersVerbal Behavior

Identifiers

PMID26435268
PMCPMC4626407
OpenAlexW2163486744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.