Evidence map›Paper›PMID 26435117›Full record

ArticleJournal of the American College of Radiology : JACR2015

Opportunistic Osteoporosis Screening: Addition of Quantitative CT Bone Mineral Density Evaluation to CT Colonography.

Timothy J Ziemlewicz, Neil Binkley, Perry J Pickhardt

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Journal of the American College of Radiology : JACR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 51 citations in OpenAlex.

  1. Future Osteoporotic Fracture Risk Related to Lumbar Vertebral Trabecular Attenuation Measured at Routine Body CT.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
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  12. Ten-year fracture risk predicted by proximal femur Hounsfield units.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020
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  20. Osteoporosis and Hip Fracture Risk From Routine Computed Tomography Scans: The Fracture, Osteoporosis, and CT Utilization Study (FOCUS).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin.
Neil BinkleyDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin.
Perry J PickhardtDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, Wisconsin. Electronic address: ppickhardt2@uwhealth.org.
University of Wisconsin–Madison · US

Funding

Virtual Colonoscopy and Colorectal Cancer ScreeningR01CA144835 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI PICKHARDT, PERRY, SMITH, MAUREEN A · 2010 to 2013
$2.1M
NCI NIH HHS R01 CA144835
6 · The paper itself

Abstract

purposeFor patients undergoing CT colonography (CTC), the screening presents an opportunity for concurrent osteoporosis screening, without increasing radiation exposure or the time involved for the patient, using proximal femur quantitative CT-CT x-ray absorptiometry (QCT-CTXA).

methodsThis cohort included 129 women and 112 men (mean age: 60.1 ± 8.2 years; range: 50-95 years) who underwent CTC between March 2013 and September 2014. Areal bone mineral density (BMD; g/cm(2)), and resultant left femoral neck T-score, was prospectively measured on the supine CT series. QCT results were reported with the CTC. Chart review evaluated whether the patients were eligible for BMD screening according to guidelines from the US Preventive Services Task Force and the National Osteoporosis Foundation guidelines; whether they had undergone prior BMD testing; and whether QCT results changed patient management.

resultsOverall, 68.0% (164 of 241) of patients from this cohort had not previously undergone BMD screening. According to the National Osteoporosis Foundation guidelines, 44.0% (106 of 241) of patients were eligible for screening. T-scores within the osteopenic and osteoporotic range were detected in 32.3% (78 of 241) and 5.0% (12 of 241) of patients, respectively. Of these patients with low BMD, 66.7% (60 of 90) either had not previously undergone screening or were eligible for BMD testing. Reporting of QCT-CTXA T-scores altered management in 9 patients (3.7%) who had low BMD.

conclusionsMaximizing the pre-existing value from imaging studies is crucial in the current era of health care reform. We demonstrate that colorectal and osteoporosis screening can be combined at CT examination, adding clinical and likely economic value.

Indexed as

Absorptiometry, PhotonAgedAged, 80 and overCalcification, PhysiologicCohort StudiesColonography, Computed TomographicColorectal NeoplasmsFemaleHumansMaleMass ScreeningMiddle AgedMultimodal ImagingOsteoporosisReproducibility of ResultsSensitivity and Specificitybone mineral densityCT colonographyosteoporosisScreening

Identifiers

PMID26435117
PMCPMC5514547
OpenAlexW1907772473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.