SynthesisThe Journal of physiology2016
Retinal vascular imaging in early life: insights into processes and risk of cardiovascular disease.
Synthesis in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Computational Quantification of Mouse Retinal Vasculature Using ImageJ.Bio-protocol · 2026Article
- Body Roundness Index and Reported Vision Difficulty in U.S. Children and Adolescents: A Cross-Sectional Study of NHANES 2021-2023.Healthcare (Basel, Switzerland) · 2026Article
- High-accuracy retinal age prediction via fundus-based multitask learning reveals the effect of systemic disease.Communications medicine · 2026Article
- The role of the infrapatellar fat pad in osteoporotic knee osteoarthritis: bone-fat crosstalk: cross-sectional studies.Journal of orthopaedic surgery and research · 2025Article
- A Method for Peripapillary Retinal Vessel Tortuosity Measurement and Its Clinical Correspondence.Translational vision science & technology · 2025Article
- Maternal Smoking Intensity During Pregnancy and Early Adolescent Cardiovascular Health.Journal of the American Heart Association · 2025Article
- Role of Maternal Vitamin DJournal of the American Heart Association · 2025Article
- Imaging the eye as a window to brain health: frontier approaches and future directions.Journal of neuroinflammation · 2024Review
- Preconception maternal retinal venular widening and steeper resistance increments in the utero-fetoplacental circulation in pregnancy.iScience · 2023Article
- Influence of secondhand smoke exposure on the retinal vasculature of children in Hong Kong.Communications medicine · 2023Article
- Association between cardiovascular health metrics and retinal ageing.GeroScience · 2023Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
- Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke.The British journal of ophthalmology · 2022Article
- The Need for Individualized Risk Assessment in Cardiovascular Disease.Journal of personalized medicine · 2022Review
- Neurostructural correlates of retinal microvascular caliber in adolescent bipolar disorder.JCPP advances · 2021Article
- Retinal microvasculature and time to pregnancy in a multi-ethnic pre-conception cohort in Singapore.Human reproduction (Oxford, England) · 2021Article
- Superficial Macula Capillary Complexity Changes Are Associated With Disability in Neuromyelitis Optica Spectrum Disorders.Frontiers in neurology · 2021Article
- Relationship of Gensini score with retinal vessel diameter and arteriovenous ratio in senile CHD.Open life sciences · 2021Article
- Noninvasive temporal detection of early retinal vascular changes during diabetes.Scientific reports · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent years, studies have shown that the origins of CVD may be traced to vascular and metabolic processes in early life. Retinal vascular imaging is a new technology that allows detailed non-invasive in vivo assessment and monitoring of the microvasculature. In this systematic review, we described the application of retinal vascular imaging in children and adolescents, and we examined the use of retinal vascular imaging in understanding CVD risk in early life. We reviewed all publications with quantitative retinal vascular assessment in two databases: PubMed and Scopus. Early life CVD risk factors were classified into four groups: birth risk factors, environmental risk factors, systemic risk factors and conditions linked to future CVD development. Retinal vascular changes were associated with lower birth weight, shorter gestational age, low-fibre and high-sugar diet, lesser physical activity, parental hypertension history, childhood hypertension, childhood overweight/obesity, childhood depression/anxiety and childhood type 1 diabetes mellitus. In summary, there is increasing evidence supporting the view that structural changes in the retinal microvasculature are associated with CVD risk factors in early life. Thus, the retina is a useful site for pre-clinical assessment of microvascular processes that may underlie the future development of CVD in adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.