Evidence map›Paper›PMID 26435004›Full record

ArticleThe Journal of allergy and clinical immunology2016

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

Sidra M Hoffman, David G Chapman, Karolyn G Lahue, Jonathon M Cahoon, Gurkiranjit K Rattu, Nirav Daphtary, Minara Aliyeva, Karen A Fortner, Serpil C Erzurum, Suzy A A Comhair and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Mitoquinone mesylate attenuates pathological features of lean and obese allergic asthma in mice.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  9. Article
  10. Article
  11. Mitochondrial ProteinFrontiers in pharmacology · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Mechanisms Targeting the Unfolded Protein Response in Asthma.American journal of respiratory cell and molecular biology · 2021
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Sidra M HoffmanDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT.
David G ChapmanDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT; Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, Australia.
Karolyn G LahueDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT.
Jonathon M CahoonDepartment of Biology, University of Vermont, Burlington, VT.
Gurkiranjit K RattuDepartment of Biology, University of Vermont, Burlington, VT.
Nirav DaphtaryDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT.
Minara AliyevaDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT.
Karen A FortnerDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT.
Serpil C ErzurumDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Suzy A A ComhairDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Prescott G WoodruffDepartment of Medicine, University of California, San Francisco, Calif.
Nirav BhaktaDepartment of Medicine, University of California, San Francisco, Calif.
Anne E DixonDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT.
Charles G IrvinDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT.
Yvonne M W Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT.
Matthew E PoynterDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT.
Vikas AnathyDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT. Electronic address: Vikas.anathy@med.uvm.edu.
University of Vermont · USCleveland Clinic Lerner College of Medicine · USUniversity of California, San Francisco · USWoolcock Institute of Medical Research · AU

Funding

Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REIZES, OFER · 2011 to 2020
$26.8M
Tissue Processing and Cell Culture COreP01HL081064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2006 to 2019
$17.8M
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
Vermont Immunobioloigy/ Infectious Diseases CenterP20GM103496 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2012 to 2015
$8.7M
REGULATION OF NFKB IN LUNG EPITHELIUM BY ROS/RNSR01HL060014 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 1999 to 2016
$5.9M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Redox-based Fas Signaling in Allergic Airway DiseaseR01HL079331 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2005 to 2016
$4.2M
Translational Research in Lung Biology and DiseaseP30GM103532 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI IRVIN, CHARLES G · 2012 to 2016
$3.7M
Endoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5M
Epithelial JNK-TGFb1 Signaling Axis in Airway RemodelingR01HL085464 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2008 to 2016
$3.0M
Translational research on the role of IL-17 cytokines in severe asthmaK23HL116657 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BHAKTA, NIRAV RATI · 2014 to 2018
$782k
NHLBI NIH HHS HL081064NHLBI NIH HHS HL103453NHLBI NIH HHS K23 HL116657NHLBI NIH HHS P01 HL081064NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R01 HL060014NHLBI NIH HHS R01 HL079331NHLBI NIH HHS R01HL079331NHLBI NIH HHS R01 HL085464NHLBI NIH HHS R01 HL122383NHLBI NIH HHS R01HL122383NHLBI NIH HHS R24 HL123767NHLBI NIH HHS U10 HL109250NIGMS NIH HHS P20 GM103496NIGMS NIH HHS P20GM103496NIGMS NIH HHS P30 GM103532NIGMS NIH HHS P30GM103532
6 · The paper itself

Abstract

backgroundEvidence for association between asthma and the unfolded protein response is emerging. Endoplasmic reticulum resident protein 57 (ERp57) is an endoplasmic reticulum-localized redox chaperone involved in folding and secretion of glycoproteins. We have previously demonstrated that ERp57 is upregulated in allergen-challenged human and murine lung epithelial cells. However, the role of ERp57 in asthma pathophysiology is unknown.

objectivesHere we sought to examine the contribution of airway epithelium-specific ERp57 in the pathogenesis of allergic asthma.

methodsWe examined the expression of ERp57 in human asthmatic airway epithelium and used murine models of allergic asthma to evaluate the relevance of epithelium-specific ERp57.

resultsLung biopsy specimens from asthmatic and nonasthmatic patients revealed a predominant increase in ERp57 levels in epithelium of asthmatic patients. Deletion of ERp57 resulted in a significant decrease in inflammatory cell counts and airways resistance in a murine model of allergic asthma. Furthermore, we observed that disulfide bridges in eotaxin, epidermal growth factor, and periostin were also decreased in the lungs of house dust mite-challenged ERp57-deleted mice. Fibrotic markers, such as collagen and α smooth muscle actin, were also significantly decreased in the lungs of ERp57-deleted mice. Furthermore, adaptive immune responses were dispensable for house dust mite-induced endoplasmic reticulum stress and airways fibrosis.

conclusionsHere we show that ERp57 levels are increased in the airway epithelium of asthmatic patients and in mice with allergic airways disease. The ERp57 level increase is associated with redox modification of proinflammatory, apoptotic, and fibrotic mediators and contributes to airways hyperresponsiveness. The strategies to inhibit ERp57 specifically within the airways epithelium might provide an opportunity to alleviate the allergic asthma phenotype.

Indexed as

AllergensAnimalsAsthmabcl-2 Homologous Antagonist-Killer ProteinBiopsyB-LymphocytesCaspase 3CytokinesDisease Models, AnimalFemaleFibrosisGene ExpressionHumansLungMaleMiceAllergensbcl-2 Homologous Antagonist-Killer ProteinCaspase 3CytokinesPDIA3 protein, humanProtein Disulfide-Isomerasesairways hyperresponsivenessasthmaendoplasmic reticulum protein 57endoplasmic reticulum stressepitheliumhouse dust miteprotein disulfide isomeraserecombination-activating gene 1Unfolded protein response

Identifiers

PMID26435004
PMCPMC4597791
OpenAlexW1855773678

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.