ArticleMayo Clinic proceedings2015
Association of Cardiorespiratory Fitness With Coronary Heart Disease in Asymptomatic Men.
Article in Mayo Clinic proceedings, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among adults: an overview of meta-analyses representing over 20.9 million observations from 199 unique cohort studies.British journal of sports medicine · 2024Pooled it
- The Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2021Pooled it
- Trial
- Traditional Chinese medicine constitution and cardiometabolic multimorbidity: a nationwide cross-sectional study in older adults.Frontiers in public health · 2026Article
- Differences in cardiorespiratory fitness improvement following phase II cardiac rehabilitation program among post-coronary artery bypass grafting patients with varied risk factor profiles.Turk gogus kalp damar cerrahisi dergisi · 2025Article
- Females Display Lower Risk of Myocardial Infarction From Higher Estimated Cardiorespiratory Fitness Than Males: The Tromsø Study 1994-2014.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024Article
- Prognostic Modelling Studies of Coronary Heart Disease-A Systematic Review of Conventional and Genetic Risk Factor Studies.Journal of cardiovascular development and disease · 2022Review
- The physiological and clinical importance of cardiorespiratory fitness in people with abdominal aortic aneurysm.Experimental physiology · 2022Review
- A multi-center, randomized, double-blinded, parallel, placebo-controlled study to assess the efficacy and safety of Shenqisuxin granule in complex coronary artery disease after PCI: Study protocol.Frontiers in cardiovascular medicine · 2022Article
- Physical Activity and Cardiorespiratory Fitness: Vital Signs for Cardiovascular Risk Assessment.Current cardiology reports · 2021Review
- How Ceramides Orchestrate Cardiometabolic Health-An Ode to Physically Active Living.Metabolites · 2021Review
- Cardiometabolic-Based Chronic Disease, Addressing Knowledge and Clinical Practice Gaps: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020Review
- Cardiorespiratory Fitness and the Risk of First Acute Myocardial Infarction: The HUNT Study.Journal of the American Heart Association · 2019Article
- Promoting the Assessment of Physical Activity and Cardiorespiratory Fitness in Assessing the Role of Vascular Risk on Cognitive Decline in Older Adults.Frontiers in physiology · 2019Article
- Predicting Cardiovascular Disease Among Testicular Cancer Survivors After Modern Cisplatin-based Chemotherapy: Application of the Framingham Risk Score.Clinical genitourinary cancer · 2018Article
- Evaluation of the convergent validity of an estimated cardiorespiratory fitness algorithm.European journal of applied physiology · 2018Article
- Cardiorespiratory Fitness and Cardiovascular Disease Prevention: an Update.Current atherosclerosis reports · 2018Review
- Overweight and obesity are progressively associated with lower work ability in the general working population: cross-sectional study among 10,000 adults.International archives of occupational and environmental health · 2017Article
- Addition of estimated cardiorespiratory fitness to the clinical assessment of 10-year coronary heart disease risk in asymptomatic men.Preventive medicine reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association of cardiorespiratory fitness (CRF) with risk of coronary heart disease (CHD) while controlling for an individual's Framingham Risk Score (FRS)-predicted CHD risk. PATIENTS AND
methodsThe study included 29,854 men from the Aerobics Center Longitudinal Study, who received a baseline examination from January 1, 1979, to December 31, 2002. Coronary heart disease events included self-reported myocardial infarction or revascularization or CHD death. Multivariable survival analysis investigated the association between CRF, FRS, and CHD. Cardiorespiratory fitness was analyzed as both a continuous and a categorical variable. The population was stratified by "low" and "moderate or high" risk of CHD to test for differences in the FRS stratified by CRF.
resultsCompared with men without incident CHD, men with incident CHD were older (mean age, 51.6 years vs 44.6 years), had lower average maximally achieved fitness (10.9 metabolic equivalent of tasks vs 12.0 metabolic equivalent of tasks [METs]), and were more likely to have moderate or high 10-year CHD risk (P<.001). Cardiorespiratory fitness, defined as maximal METs, exhibited a 20% lower risk of CHD (hazard ratio, 0.80; 95% CI, 0.77-0.83) for each 1-unit MET increase. Among men in the low CRF strata, individuals with moderate or high 10-year CHD risk, according to the FRS, had a higher CHD risk (hazard ratio, 6.55; 95% CI, 3.64-11.82) than men with low CHD risk according to the FRS.
conclusionClinicians should promote physical activity to improve CRF so as to reduce CHD risk, even to patients with otherwise low CHD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.