Evidence map›Paper›PMID 26434947›Full record

ReviewExpert review of vaccines2015

Development of next-generation respiratory virus vaccines through targeted modifications to viral immunomodulatory genes.

Christopher C Stobart, Martin L Moore

Abstract readReview
In one paragraph

Review in Expert review of vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Christopher C Stobarta 1 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Martin L Moorea 1 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Children's Healthcare of Atlanta · USEmory University · US

Funding

Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tina V Hartert · 2011 to 2026
$34.9M
Training a New Generation of VaccinologistsT32AI074492 · NIAID · EMORY UNIVERSITY · PI Rama Rao Amara, Benjamin A Lopman · 2009 to 2026
$6.4M
Role of the Respiratory Syncytial Virus Fusion Protein in Airway Mucus InductionR01AI087798 · NIAID · EMORY UNIVERSITY · PI MOORE, MARTIN LAWRENCE · 2010 to 2014
$1.9M
NIAID NIH HHS R01 AI087798NIAID NIH HHS R01AI087798NIAID NIH HHS T32 AI074492NIAID NIH HHS U19 AI095227
6 · The paper itself

Abstract

Vaccines represent one of the greatest contributions of the scientific community to global health. Yet, many pathogens remain either unchallenged or inadequately hindered by commercially available vaccines. Respiratory viruses pose distinct and difficult challenges due to their ability to rapidly spread, adapt, and modify the host immune response. Considerable research has been directed to understand the role of respiratory virus immunomodulatory proteins and how they influence the host immune response. We review here efforts to develop next-generation vaccines through targeting these key immunomodulatory genes in influenza virus, coronaviruses, respiratory syncytial virus, measles virus, and mumps virus.

Indexed as

CoronavirusCoronavirus InfectionsHumansInfluenza, HumanMeaslesMeasles virusMumpsMumps virusOrthomyxoviridaeRespiratory Syncytial VirusesRespiratory Tract InfectionsVaccines, AttenuatedVaccines, SubunitViral VaccinesVaccines, AttenuatedVaccines, SubunitViral Vaccinescoronavirusimmunologyinfluenzameaslesmumpsnext-generation vaccinespathogenesisrespiratory syncytial virusrespiratory viruses

Identifiers

PMID26434947
PMCPMC4889331
OpenAlexW2175488369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.