ArticleGenetics2015
The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the NematodeCells · 2025Review
- Study on the effect of GCY-12 gene on albendazole sensitivity ofFrontiers in veterinary science · 2025Article
- Comparative analysis of phosphorylated proteomes between plerocercoid and adult Spirometra mansoni reveals phosphoproteomic profiles of the medical tapeworm.Parasites & vectors · 2024Article
- The New Nematicide Cyclobutrifluram Targets the Mitochondrial Succinate Dehydrogenase Complex inInternational journal of molecular sciences · 2024Article
- Positive interaction between ASH and ASK sensory neurons accelerates nociception and inhibits behavioral adaptation.iScience · 2022Article
- The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision.Nature communications · 2022Article
- ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans.PLoS biology · 2022Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity.Theranostics · 2021Review
- Molecular Effects of Silver Nanoparticles on Monogenean Parasites: Lessons fromInternational journal of molecular sciences · 2020Article
- High-throughput transcriptome sequencing reveals extremely high doses of ionizing radiation-response genes inToxicology research · 2019Article
- Active propagation of dendritic electrical signals in C. elegans.Scientific reports · 2019Article
- High-content behavioral profiling reveals neuronal genetic network modulating Drosophila larval locomotor program.BMC genetics · 2017Article
- Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.Scientific reports · 2017Article
- Receptor Guanylyl Cyclases in Sensory Processing.Frontiers in endocrinology · 2016Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The body size of Caenorhabditis elegans is thought to be controlled by sensory inputs because many mutants with sensory cilium structure defects exhibit small body size. The EGL-4 cGMP-dependent protein kinase acts in sensory neurons to reduce body size when animals fail to perceive sensory signals. In addition to body size control, EGL-4 regulates various other behavioral and developmental pathways, including those involved in the regulation of egg laying and chemotaxis behavior. Here we have identified gcy-12, which encodes a receptor-type guanylyl cyclase, as a gene involved in the sensory regulation of body size. Analyses with GFP fusion constructs showed that gcy-12 is expressed in several sensory neurons and localizes to sensory cilia. Genetic analyses indicated that GCY-12 acts upstream of EGL-4 in body size control but does not affect other EGL-4 functions. Our studies indicate that the function of the GCY-12 guanylyl cyclase is to provide cGMP to the EGL-4 cGMP-dependent kinase only for limited tasks including body size regulation. We also found that the PDE-2 cyclic nucleotide phosphodiesterase negatively regulates EGL-4 in controlling body size. Thus, the cGMP level is precisely controlled by GCY-12 and PDE-2 to determine body size through EGL-4, and the defects in the sensory cilium structure may disturb the balanced control of the cGMP level. The large number of guanylyl cyclases encoded in the C. elegans genome suggests that EGL-4 exerts pleiotropic effects by partnering with different guanylyl cyclases for different downstream functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.