ArticleGenetics2015
The Effects of Background and Interference Selection on Patterns of Genetic Variation in Subdivided Populations.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.Evolution; international journal of organic evolution · 2025Article
- FST and genetic diversity in an island model with background selection.PLoS genetics · 2024Article
- Repeated evolution on oceanic islands: comparative genomics reveals species-specific processes in birds.BMC ecology and evolution · 2024Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.bioRxiv : the preprint server for biology · 2024Article
- Linked selection and the evolution of altruism in family-structured populations.Ecology and evolution · 2024Article
- Genomics of plant speciation.Plant communications · 2023Review
- The role of recombination landscape in species hybridisation and speciation.Frontiers in plant science · 2023Review
- Article
- Article
- Global adaptation complicates the interpretation of genome scans for local adaptation.Evolution letters · 2021Article
- Methods for Estimating Demography and Detecting Between-Locus Differences in the Effective Population Size and Mutation Rate.Molecular biology and evolution · 2019Article
- Article
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Ancient hybridization and strong adaptation to viruses across African vervet monkey populations.Nature genetics · 2017Article
- Estimating the parameters of background selection and selective sweeps inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Relative Contributions of theGenetics · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is well known that most new mutations that affect fitness exert deleterious effects and that natural populations are often composed of subpopulations (demes) connected by gene flow. To gain a better understanding of the joint effects of purifying selection and population structure, we focus on a scenario where an ancestral population splits into multiple demes and study neutral diversity patterns in regions linked to selected sites. In the background selection regime of strong selection, we first derive analytic equations for pairwise coalescent times and FST as a function of time after the ancestral population splits into two demes and then construct a flexible coalescent simulator that can generate samples under complex models such as those involving multiple demes or nonconservative migration. We have carried out extensive forward simulations to show that the new methods can accurately predict diversity patterns both in the nonequilibrium phase following the split of the ancestral population and in the equilibrium between mutation, migration, drift, and selection. In the interference selection regime of many tightly linked selected sites, forward simulations provide evidence that neutral diversity patterns obtained from both the nonequilibrium and equilibrium phases may be virtually indistinguishable for models that have identical variance in fitness, but are nonetheless different with respect to the number of selected sites and the strength of purifying selection. This equivalence in neutral diversity patterns suggests that data collected from subdivided populations may have limited power for differentiating among the selective pressures to which closely linked selected sites are subject.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.