ArticleScientific reports2015
Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Exposure to violence, chronic stress, nasal DNA methylation, and atopic asthma in children.Pediatric pulmonology · 2021Pooled it
- Correlation of AHR Activation-Induced Suppression of PWM-Stimulated IgG and IgG-Triggered Signaling in Human PBMCs.Antibodies (Basel, Switzerland) · 2026Article
- Steroid hormone antagonism affords vascular protection in a mouse model of vascular Ehlers-Danlos syndrome.JCI insight · 2026Article
- Genomic Regions Associated with Respiratory Disease in Holstein Calves in the Southern United States.Genes · 2025Article
- Chrysin improves endothelial inflammation via the NFAT pathway in Kawasaki disease.Molecular biology reports · 2025Article
- A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers.Frontiers in immunology · 2025Article
- Sex-Specific Susceptibility Loci Associated With Coronary Artery Aneurysms in Patients With Kawasaki Disease.Korean circulation journal · 2024Article
- Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease.NPJ genomic medicine · 2024Article
- Comparative single-cell analysis of the adult heart and coronary vasculature.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Article
- Chronic Obstructive Pulmonary Disease: Novel Genes Detection with Penalized Logistic Regression.Cell journal · 2023Article
- Article
- Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease.European journal of human genetics : EJHG · 2021Article
- Identification of rare coding variants associated with Kawasaki disease by whole exome sequencing.Genomics & informatics · 2021Article
- The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation.Frontiers in endocrinology · 2021Article
- Article
- Selection signatures of litter size in Dazu black goats based on a whole genome sequencing mixed pools strategy.Molecular biology reports · 2019Article
- Identification of the TIFAB Gene as a Susceptibility Locus for Coronary Artery Aneurysm in Patients with Kawasaki Disease.Pediatric cardiology · 2019Article
- Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation and Inflammation in Kawasaki Disease.Indian journal of pediatrics · 2019Article
- Current State of Precision Medicine in Primary Systemic Vasculitides.Frontiers in immunology · 2019Review
- Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.American journal of respiratory and critical care medicine · 2018Article
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis affecting infants and young children. Coronary artery aneurysm (CAA) formation is the major complication of KD and the leading cause of acquired cardiovascular disease among children. To identify susceptible loci that might predispose patients with KD to CAA formation, a genome-wide association screen was performed in a Taiwanese KD cohort. Patients with both KD and CAA had longer fever duration and delayed intravenous immunoglobulin treatment time. After adjusting for these factors, 100 susceptibility loci were identified. Four genes were identified from a single cluster of 35 using the Ingenuity Pathway Analysis (IPA) Knowledge Base. Silencing KCNQ5, PLCB1, PLCB4, and PLCL1 inhibited the effect of lipopolysaccharide-induced endothelial cell inflammation with varying degrees of proinflammatory cytokine expression. PLCB1 showed the most significant inhibition. Endothelial cell inflammation was also inhibited by using a phospholipase C (PLC) inhibitor. The single nucleotide polymorphism rs6140791 was identified between PLCB4 and PLCB1. Plasma PLC levels were higher in patients with KD and CC+CG rs6140791genotypes, and these genotypes were more prevalent in patients with KD who also had CAA. Our results suggest that polymorphism of the PLCB4/B1 genes might be involved in the CAA pathogenesis of KD.
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